Epigenetics in human disease and prospects for epigenetic therapy

By Gerda Egger, G. Liang, A. Aparicio, Peter A. Jones. Nature, 2004

3,264 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/73d5cb59b06c87b6f3e87522259c612b0bb47d17

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Citations in the corpus

High-throughput DNA methylation profiling using universal bead arrays. (2006, background): “DNA methylation is widespread and plays a critical role in the regulation of gene expression in development, differentiation, and diseases such as multiple sclerosis, diabetes, schizophrenia, aging, and cancers (Li et al. 1993; Laird and Jaenisch 1996; Egger et al. 2004).”
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine (2008, background): “This has established azacytidine and decitabine as archetypal drugs for epigenetic cancer therapies.(9)”
DNA methylation presents distinct binding sites for human transcription factors (2013, background): “On the other hand, consistent with the important role of DNA methylation in the development of cancer (Egger et al., 2004; Reik, 2007), there was a significant enrichment for known oncogenes and tumor suppressors (10/47; p<0.”
Epigenetic Modifications as Therapeutic Targets (2010, background): “Expression of the DNA repair gene O(6)-methylguanine-DNA methyltransferase (MGMT) antagonizes chemotherapy and radiation treatment18 thus, silencing of MGMT by hypermethylation correlates with positive treatment response.”
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? (2006, background): “However, the chromatin events that are involved in the epigenetic determinants of cancer, such as promoter methylation and histone modifications that are associated with defects in transcriptional repression, have real potential for drug targeting, as silenced genes can be induced to re-expres”
Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, background): “In this context, there is also a need to identify small molecular inhibitors of PRC1 and PRC2 as these could have a use in emerging strategies for epigenetic therap”
DNA methylation and healthy human aging (2015, background): “This phenomenon has been referred to as ‘epigenetic drift’ (Egger et al., 2004; Martin, 2005).”
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. (2006, background): “DNA methylation and histone modification play critical roles in chromatin remodeling and general regulation of gene expression in mammalian development and human diseases, such as cancer (Egger et al., 2004).”
Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “ylated than active ones (128), the reason being that methyl groups reduce DNA-binding capacity of transcrip-”
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006, background): “Indirectly, the observation that alterations of other chromatin modifiers can be observed in tumours is an additional link to deregulation in the balance of histone acetylation — both DNA and histone methylation are tightly linked to repressive chromatin states and at least partially dependent on th”
Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain (2010, background): “gene product has been most often described [8].”
The epigenetic progenitor origin of human cancer (2006, background): “Pathological epigenetic changes — non-sequence-based alterations that are inherited through cell division — are increasingly being considered as alternatives to mutations and chromosomal alterations in disrupting gene functio”
CpG island methylator phenotype in cancer (2004, background): “Genetic anomalies in DNA methylation (or associated mechanisms) leads to various developmental diseases in human”