Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker.

By M. Pepe, H. Janes, G. Longton, W. Leisenring, P. Newcomb. American Journal of Epidemiology, 2004

1,337 citations recorded by the source corpus.

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Citations in the corpus

Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. (2005, methodology): “In addition, we estimated the absolute risk associated with each candidate risk factor and constructed receiver operating characteristic (ROC) curves to estimate the aggregate predictive utility of traditional and novel risk factors.(11)”
Towards better clinical prediction models: seven steps for development and an ABCD for validation. (2014, background): “that markers with statistically significant effects, but with a modest relative effect size, will not impact tremendously on identifying those with or without the endpoint.(48) Cost-effectiveness analyses should eventually guide us on the question whether an increase in”
Gestational diabetes and pregnancy outcomes - a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria (2012, background): “Nevertheless, even if GDM diagnostic criteria were to reach relative risks close to 3 for these adverse outcomes in such settings, the relative risks would still be unlikely to reflect major diagnostic discrimination in terms of post test probabilities [21].”
Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. (2014, background): “[39] Pepe MS, Janes H, Longton G, Leisenring W, Newcomb P.”
Prognosis Research Strategy (PROGRESS) 3: Prognostic Model Research (2013, background): “Because standard models generally include important predictors, the independent effects of new prognostic factors need to be quite strong before a clinically useful improvement is achieved [54].”
Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond (2008, background): “Ware and Pepe show simple examples in which enormous odds ratios are required to meaningfully increase the AUC [ 19 , 21].”
Assessing the performance of prediction models: a framework for some traditional and novel measures (2010, background): “Predictions are hence absolute risks, which go beyond assessments of relative risks, such as regression coefficients, odds ratios, or hazard ratios.(2) There are various ways to assess the performance of a statistical prediction model.”