The history of cancer epigenetics

By Andrew P. Feinberg, Benjamin Tycko. Nature Reviews. Cancer, 2004

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View Paper: https://www.semanticscholar.org/paper/68ccc8f47869c58f190fd37fa856f21e441aaab4

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Citations in the corpus

BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing (2005, methodology): “In an easy-to-use manner, the tool helps the user to import the sequence files from the sequencer, to align them, to exclude or correct critical sequences, to document the experiment, to perform basic statistics and to produce publication-quality diagrams.”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Human cancers often exhibit characteristic changes in DNA methylation, including genome-wide hypomethylation and site-specific hypermethylation (Jones and Baylin, 2002; Feinberg and Tycko, 2004).”
Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair (2011, neutral): “, 2001), and characteristic epigenetic changes in cancer, such as global genome hypomethylation and tumor suppressor gene hypermethylation (Feinberg and Tycko, 2004; Jones and Laird, 1999).”
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays (2014, neutral): “DNAm is best understood in the context of cancer biology, where it is clear that aberrant gains and losses of DNAm almost universally accompany the initiation and progression of tumors (Feinberg and Tycko, 2004).”
Functional normalization of 450k methylation array data improves replication in large cancer studies (2014, neutral): “, 21287, Baltimore, USA Full list of author information is available at the end of the article their methylome compared to normal samples from the same tissue of origin, making the marginal distribution of methylation across the genome different between cancer and normal samples [4-8]; see Additiona”
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis (2013, background): “This may be due in part to several limitation to such studies including (1) the cellular heterogeneity of the sample material, and (2) the potential for methylation changes that are a consequence of disease rather than part of the etiology Here, we apply a series of ad hoc filtering steps that addre”
Intra-individual change over time in DNA methylation with familial clustering. (2008, background): “For example, cancer is associated with both hypomethylation and hypermethylation through activation of oncogenes and silencing of tumor suppressor genes, respectively.(28) Similarly, animal studies have shown that a loss of DNA methylation increases intestinal adenoma initiation and a gain of DNA me”
Cancer epigenetics: from mechanism to therapy. (2012, background): “These studies are too numerous to comprehensively detail in this review; however, the reader is referred to an excellent review detailing the history of cancer epigenetics (Feinberg and Tycko, 2004).”
DNA methylation and human disease (2005, background): “DNA methylation and cancer A link between DNA methylation and cancer was first demonstrated in 1983, when it was shown that the genomes of cancer cells are hypomethylated relative to their normal counterpart”
Mendelian Inheritance in Man and Its Online Version, OMIM (2007, neutral): “41 A large interest of MIM/OMIM in chromosomal aberrations is in connection with gene mapping.”
Cancer genes and the pathways they control (2004, background): “and are often associated with 'epigenetic' changes—that is, covalent modifications of DNA or chromatin that are preserved as the cancer cells divid”