Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

By O. Berton, Colleen A. Mcclung, R. DiLeone, V. Krishnan, W. Renthal, S. Russo, Danielle L. Graham, Nadia M. Tsankova, C. Bolaños, M. Rios and 3 more. Science, 2006

2,056 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/be90e581ed99ea918c88597adc4fad07aeb2ec4d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. E. Nestler
2. V. Krishnan
3. Eero Castrén
4. R. Duman
5. L. Monteggia
6. J. Cryan
7. T. Rantamäki
8. Ted G. Dinan

In Cellular and Molecular Neuroscience

1. E. Nestler
2. R. Duman
3. L. Monteggia
4. H. Schmidt
5. V. Krishnan
6. T. Rantamäki
7. Eero Castrén
8. Anita E. Autry

In Social Psychology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. Debra Rickwood
6. C. Wilson
7. R. Duman
8. H. Schmidt

Citations in the corpus

• New insights into BDNF function in depression and anxiety (2007, background): “Moreover, emerging evidence indicates that BDNF may have different and perhaps opposing roles in the brain stress system, including the hippocampus and hypothalamus-pituitary-adrenocortical (HPA) axis, and in the brain reward system, including the nucleus accumbens (NAc) and the ventral tegmental ar”
• Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression (2008, background): “…responses to dextroamphetamine (Drevets et al, 2001), cocaine-induced euphoria (Breiter et al, 1997), monetary reward (Cohen et al, 2005; Knutson et al, 2001a; O'Doherty et al, 2001), pleasurable responses to music (Blood and Zatorre, 2001), and viewing attractive faces (Aharon et al, 2001).”
• Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “BDNF has been shown to regulate VTA DA neurons (Conner et al., 1997), and alterations in BDNF can influence mesolimbic DA responses to reward and resiliency to stress (Berton et al., 2006; Cordeira et al.).”
• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, neutral): “In the mouse social defeat paradigm, while stress-susceptible mice display enhanced VTA activity and subsequent BDNF release, stress-resilient mice overcome this excitability change by upregulating potassium channel subunits expressed by VTA dopamine neurons that maintain normal tonic firing rates (”
• Psychobiology and molecular genetics of resilience (2009, neutral): “Chronic stress increases BDNF expression in the rodent nucleus accumbens, and this has been linked to pro-depression-like effects in several behavioural assay”
• Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, methodology): “Using a social defeat paradigm, Berton et al (2006) recently showed that repeated exposure to aggression results in long-lasting social withdrawal in mice.”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Consistent with this finding, decreased expression of BDNF in the VTA produces an antidepressant-like effect in a social defeat stress paradigm (Berton et al., 2006).”
• ΔFosB Induction in Orbitofrontal Cortex Mediates Tolerance to Cocaine-Induced Cognitive Dysfunction (2007, methodology): “Microarray analysis was performed as described previously (McClung and Nestler, 2003; McClung et al., 2005; Berton et al., 2006) with few modifications.”
• Depressive symptoms and help-seeking intentions in young people (2007, positive): “Recent animal neuroscience research has confirmed that social withdrawal is associated with the brain changes related to depression (Berton et al., 2006).”
• Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. (2007, methodology): “Increased BDNF Signaling within the NAc Mediates Susceptibility Because chronic social defeat increases BDNF protein levels in the NAc on days 11 and 39 (Berton et al., 2006), we tested whether this response differs between Susceptible and Unsusceptible mice.”
• Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014, methodology): “To directly address whether systemic inflammation functionally contributes to stress vulnerability, we used two social stress paradigms: repeated social defeat stress (RSDS) (13, 14) and a purely emotional stressor (witness defeat) (15).”
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “The recent discovery that BDNF in different regions of the brain may have opposing functions in modulating the stress response supports this notion (Berton et al., 2006).”
• Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. (2007, positive): “…clinical relevance, chronic but not acute imipramine treatment, which is known to reverse many of the effects of chronic social defeat stress (Berton et al., 2006; Tsankova et al., 2006), upregulated Hdac5 mRNA expression in the NAc, suggesting that HDAC5 function in the NAc may be an…”