Psychobiology and molecular genetics of resilience

By A. Feder, E. Nestler, Dennis S. Charney. Nature Reviews Neuroscience, 2009

1,253 citations recorded by the source corpus.

Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Clinical Psychology

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Citations in the corpus

Resilience and mental health. (2010, neutral): “…the rewarding value of social stimuli, empathy, trust and in reducing potential fear responses (Bakermans-Kranenburg & van Ijzendoorn, 2008; Feder et al., 2009) oxytocin may be a resilience factor in the context of secure social attachments associated with passive coping strategies but a…”
Annual Research Review: Positive adjustment to adversity -Trajectories of minimal-impact resilience and emergent resilience (2012, neutral): “Finally, there is the compelling question of the neuroscience of resilience (Feder et al., 2009; Ryff & Singer, 2002; Ryff et al., 2004).”
The Buffering Effect of Resilience upon Stress, Anxiety and Depression in Parents of a Child with an Autism Spectrum Disorder (2013, background): “Although initially investigated as a psychological variable, resilience has recently been shown to have a biological basis that relies upon plasticity of the reward and fear circuits in the brain (Bergstrom et al. 2007; Feder et al. 2009), with 11 possible neurological mediators of the resilient res”
Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness (2012, methodology): “These metaphors have been used similarly to previous theoretical models for psychoneuroimmunology (Ader et al., 1987; Feder et al., 2009), and are used here to describe the expression of equanimity that is tightly-coupled with the skills of mindful awareness.”
Understanding resilience (2013, background): “Psychobiological qualities important in prosocial behavior include emotion regulation, empathy, and altruism, among others (Charney, 2004; Feder et al., 2009).”
Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory (2011, background): “…[NE], serotonin, dopamine, neuropeptide Y, and brain-derived neurotrophic factor) are involved in the activation and regulation of these circuits, along with polymorphisms and haplotypes within the genes involved in the expression of signaling molecules and their receptors (Feder et al., 2009).”
Mindfulness-Based Mind Fitness Training: A Case Study of a High-Stress Predeployment Military Cohort. (2011, background): “Recent studies suggest that resilience as individual characteristics or skills could be cultivated or enhanced to confer protection from overwhelming experience (Feder et al., 2009; Haglund et al., 2007).”
Resilience to loss and potential trauma. (2011, background): “For example, resilience is sometimes defined simply as the absence of diagnosable psychopathology (e.g., Feder et al. 2009).”
Research review: the neurobiology and genetics of maltreatment and adversity. (2010, background): “For example, 5-HTT has been associated with PTSD, depression and antisocial behaviour (e.g., Cicchetti, Rogosch, & Sturge-Apple, 2007; Feder et al., 2009).”
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease (2010, background): “It is worth emphasizing that although there is an increasing number of gene polymorphisms that are associated with psychiatric disorders, recent studies on individuals' resilience to stress suggest that long-term environmental factors may have an epigenetic influence on mental healt”