Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

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Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “Short-term systemic or intra-NAc administration of nonspecific HDAC inhibitors potentiates place conditioning and locomotor responses to psychostimulants and to opiate”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “HDAC5 activity and epigenetic regulation of gene expression in the nucleus accumbens were also specifically associated 76 Genes, Brain and Behavior (2014) 13: 69–86 with chronic emotional stimuli such as cocaine exposure and social defeat stress (Renthal et al. 2007).”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “While such effects have yet to be reported for DNA methylation, modifications of histone proteins are associated with exposure to drugs of abuse and stressors in rodent models (Renthal & Nestler, 2008; Renthal et al., 2007).”
Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, unknown): “While overexpression of HDAC5 in the hippocampus counteracts the effects of antidepressants, mice that are globally deficient in HDAC5 display an enhanced vulnerability to chronic stress (48).”