Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

By T. Schlaepfer, Michael X. Cohen, C. Frick, M. Kosel, D. Brodesser, Nikolai Axmacher, A. Joe, M. Kreft, D. Lenartz, V. Sturm. Neuropsychopharmacology, 2008

965 citations recorded by the source corpus.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/e864561ceab0f0e825c5b19158de1c314cdf4b14

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In Neurology

1. Morten L. Kringelbach
2. E. Nestler
3. V. Krishnan
4. Justin Riddle
5. Josef P. Rauschecker
6. Amber M. Leaver
7. Diego A. Pizzagalli
8. Mark Mühlau

Citations in the corpus

• The molecular neurobiology of depression (2008, positive): “Deep brain stimulation, achieved through the stereotactic surgical placement of stimulating electrodes, has also provided an acute ameliorative effect on clinical ratings when applied to the nucleus accumbens (NAc”
• A common neurobiology for pain and pleasure (2008, neutral): “Evidence from human patient studies also highlights the importance of the NAc and the pallidum for reward processing, as dysregulation or lesion of these regions is associated with anhedoni”
• Pleasure systems in the brain (2015, background): “’’ Similarly, upon NAc electrode activation in a woman, the patient ‘‘did not report any acute changes in depressive symptomatology, but spontaneously mentioned that she wished to take up bowling again (a favorite pastime of hers 12 years ago, before onset of her depression)’’ (Schlaepfer et al., 20”
• Translational principles of deep brain stimulation (2007, background): “Indeed, a recent study of DBS in the nucleus accumbens found a significant reduction in anhedonia in three patients with treatment-resistant depressio”
• Memory Engram Cells Have Come of Age. (2015, positive): “Notably, the NAcc has recently been identified as a potential therapeutic node for deep brain stimulation (DBS) to alleviate anhedonia (Schlaepfer et al., 2008) in humans, and previous reports had also identified BLA axonal terminals onto NAcc as sufficient to support self-stimulation and…”
• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “Consistent with its centralized location, responders to DBS displayed normalized PET indices of activity in the nucleus accumbens and the larger ventral striatum, while also reducing activity in the subgenual cingulate cortex and other prefrontal cortical regions (19,20).”
• Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Subjects with Major Depressive Disorder (2009, background): “Given mounting interest in the role of the accumbens in the pathophysiology of major depression, as exemplified by recent deep brain stimulation studies targeting this region (35, 36), our finding of reduced rewardrelated accumbal responses is nevertheless intriguing.”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “The relevance of such dysfunction, both to pathophysiology and to future therapies, was dramatically demonstrated by the successful treatment of several cases of profoundly refractory depression by deep brain stimulation of the nucleus accumbens (Schlaepfer et al, 2007).”
• Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study (2011, background): “In particular, a blunted VS response in depression is specifically correlated with anhedonia (Keedwell et al., 2005; Wacker et al., 2009) and deep brain stimulation of the VS attenuates anhedonic symptoms (Schlaepfer et al., 2008).”