Macrophage polarization comes of age.

By A. Mantovani, A. Sica, M. Locati. Immunity, 2005

1,289 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/bd5592866d89b4c336af5a008a1aae75645f4396

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. P. Allavena
5. F. Martínez
6. Peter Libby
7. S. Badylak
8. M. Locati

In Oncology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. F. Martínez
5. P. Allavena
6. Peter Libby
7. S. Badylak
8. M. Locati

Citations in the corpus

• AMP-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype (2008, neutral): “The designations M1 and M2 have also been used to categorize macrophages expressing a proinflammatory vs an anti-inflammatory functional profile, respectively (34, 35).”
• Wound healing: cellular mechanisms and pathological outcomes (2020, background): “Like neutrophils, macrophages engulf necrotic cellular debris and pathogenic material through evolutionarily conserved receptors, but also exhibit differential behaviours and morphological changes in response to cytokines [33].”
• The extracellular matrix as a biologic scaffold material. (2007, background): “These studies suggest that macrophages differentiate toward a phenotype that is associated with either cytotoxic inflammation or constructive remodeling [80,81].”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Other factors able to influence macrophage polarization toward an M2 profile are IL10, IL-6, TGF- , and PGE2 [5, 50].”
• Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation (2010, background): “Some authors also distinguish macrophage deactivation, which is induced by cytokines, such as IL-10 or TGF-b, or by ligation of inhibitory receptors, such as CD200 receptor or CD172a, and is related to anti-inflammatory cytokine production and reduced MHC class II expression (8, 9).”
• Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1 (2006, background): “such as the mannose receptor 1 (34, 35), the scavenger receptors SR-A and M160 (3, 5, 36).”
• The Immune Landscape of Cancer (2018, background): “IL-13 influences macrophage polarization (Mantovani et al., 2005), implying a possible basis for our observation that IL-13 deletions associated with altered M0 macrophage fractions.”
• Protective immune mechanisms in helminth infection (2007, background): “Classically activated macrophages engulf and destroy microorganisms through pathways that are dependent on inducible nitric oxide synthesis (iNOS”
• Inflammation and insulin resistance (2008, background): “M1 cells express inflammatory cytokines and the cell surface marker Cd11c [41,53].”
• Macrophage activation and polarization. (2008, background): “These preferential production of IL-12 or IL-10 set the basis for the M1/M2 polarization paradigm (3, 4, 9, 10), elsewhere defined as elicitation of functionally distinct”