Wound healing: cellular mechanisms and pathological outcomes

By Holly N. Wilkinson, M. Hardman. Open Biology, 2020

1,512 citations recorded by the source corpus.

Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.

Subfields: Biomaterials, Endocrinology, Diabetes and Metabolism, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/e13d0fadccecf398cc10ad8bfbf55ce0c12d3144

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Citations in the corpus

• Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “Regeneration is a process of regrowth or repair with the capacity to maintain homeostasis, even after severe injury [3].”