The extracellular matrix as a biologic scaffold material.

By S. Badylak. Biomaterials, 2007

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Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. (2012, background): “Biologic materials composed of extracellular matrix (ECM) have been harvested from a wide variety of tissues and organs and have been used in a similarly wide variety of preclinical and clinical applications [1, 2].”
Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. (2009, background): “multiple forms of allogeneic and xenogeneic ECM from sources such as small intestine, urinary bladder, and skin have been investigated as biologic scaffolds for tissue reconstruction in both preclinical studies and human clinical applications [4,5].”
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix (2010, background): “Decellularization is an attractive technique for scaffold preparation in tissue engineering, as the resulting material can potentially retain the architecture of the original tissue, including the functional aspects of the native microvasculatur”
The extracellular matrix at a glance (2010, background): “One such example is given by porcine-derived small intestinal submucosa (SIS), which has proven clinical success for treating patients with hernias (Franklin et al., 2002) (reviewed in Badylak, 2007).”