The Immune Landscape of Cancer

By Vesteinn Thorsson, David L. Gibbs, S. Brown, D. Wolf, Dante S. Bortone, T. Yang, Eduard Porta-Pardo, G. Gao, Christopher L. Plaisier, James A. Eddy and 487 more. Immunity, 2018

4,752 citations recorded by the source corpus.

Summary We performed an extensive immunogenomic analysis of over 10,000 tumors comprising 33 diverse cancer types utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes: Wound Healing, IFN-γ Dominant, Inflammatory, Lymphocyte Depleted, Immunologically Quiet, and TGF-β Dominant, characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis. Specific driver mutations correlated with lower (CTNNB1, NRAS, or IDH1) or higher (BRAF, TP53, or CASP8) leukocyte levels across all cancers. Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes. Our immunogenomics pipeline to characterize these heterogeneous tumors and the resulting data are intended to serve as a resource for future targeted studies to further advance the field.

Subfields: Cancer Research, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/68f63280d0c7e2aa60b9c05980a9ac682a422eca

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In Cancer Research

1. W.J. Greenleaf
2. Matthew Meyerson
3. Gad Getz
4. Ansuman T. Satpathy
5. M. Lawrence
6. Abel Gonzalez-Perez
7. Núria López-Bigas
8. A. Gimenez-Roqueplo

In Oncology

1. Atsushi Tanaka
2. John N. Weinstein
3. Christopher Sander
4. Nikolaus Schultz
5. Peter W. Laird
6. Lewis R. Roberts
7. Charles M. Perou
8. Gad Getz

In Pulmonary and Respiratory Medicine

1. Mark A. Rubin
2. Marc Ladanyi
3. J. Luketich
4. Christine Lovly
5. Z. Du
6. M. Davis

Citations in the corpus

• Regulatory T Cells and Human Disease. (2020, background): “The immune signature of a tumor is linked to its tissue of origin, suggesting a link between tumor- and tissue-resident Tregs (154, 155).”
• New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx (2019, methodology): “In particular, it has been applied to identify associations between molecular subtypes and the stemness index [46] and the immune subtypes [47] of TCGA samples.”