Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1

By F. Martínez, S. Gordon, M. Locati, A. Mantovani. Journal of Immunology, 2006

1,978 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/01e52fd24d6168be425e9c1853642d36d1488434

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Citations in the corpus

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Thus, CSF-1 stimulation represents a default homeostatic/M2 pathway of monocyte development (119).”
Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “Chemokines and CSF-1 are more than monocyte attractants; they also promote M2-like skewing of macrophage function (97, 118, 119).”
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets (2019, methodology): “E) (Top to Bottom) Enrichment analysis of M1-like macrophage signature in Br-TAM: Plot suggests that M1-like genes (Martinez et al., 2006) to be positively (NES = 2.”
Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “In vitro, addition of activated M1-like macrophages to dorsal root ganglion (DRG) neuron cultures leads to axonal retraction and failure of regeneration as the expression of CSPGs is much higher in M1-like compared to M2-like macrophages (237, 238).”
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “Therefore, M2 activation is accompanied by upregulation of arachidonic acid [19], omega-3 polyunsaturated fatty acids [24], sphingosine 1-phosphate [25], eicosapentaenoic acid, and docosahexaenoic acid [26].”
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. (2014, methodology): “…FFAs upregulate proinflammatory cytokine expression in ATMs and fail to induce the M2 markers CD163, CD206, TFRC, and TGFBI (Becker et al., 2012; Martinez et al., 2006), properties that clearly distinguish these cells from M2 macrophages, which also induce lipid metabolism through PPARg…”
Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Martinez at al [48] analyzed the transcriptional profiling of the human monocyte-to-macrophage differentiation and they observed that the polarization to M1 of MCSF-differentiated macrophages was associated with the most dramatic change in the transcriptome, whereas further stimulation with an M2 st”
Tumor associated macrophages and neutrophils in cancer. (2013, background): “M2 macrophages produce chemokines such as CCL17/TARC, CCL22/MDC and CCL24/Eotaxin-2, involved in Treg cell, Th2, eosinophil and basophil recruitment (Mantovani et al. 2002; Martinez et al. 2006; Romagnani et al. 1999).”
Alternative activation of macrophages: mechanism and functions. (2010, background): “…it possible to investigate effects of IL-4 in macrophages of both species; however, given the limited number of published studies in human or mouse macrophages, a consensus of markers is hard to establish, particularly for humans (Syed et al., 2007; Martinez et al., 2006; Scotton et al., 2005).”
Novel Markers to Delineate Murine M1 and M2 Macrophages (2015, result): “To validate these data, we compared the current gene expression profiles with canonical M1 macrophage markers previously identified in mouse [23,41] or human macrophages [4,14,34].”