Age-related changes in lymphocyte development and function

By P. Linton, K. Dorshkind. Nature Immunology, 2004

1,250 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bbc4c7562d6fd719eb736359b5c6999c359febf3

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In Immunology

Citations in the corpus

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “The function of the hematopoietic system declines with age, manifested by a decreased adaptive immune response and an increased incidence of myeloproliferative diseases, autoimmune, and inflammatory disorders (Linton and Dorshkind, 2004; Ramos-Casals et al., 2003).”
Stem cells, ageing and the quest for immortality (2006, background): “It is intriguing that the changes in specific genes were correlated with the noted skewing of the lineage potential of aged HS cell”
From Vaccines to Memory and Back (2010, neutral): “It is well documented from studies in both mice and humans that the percentage of naïve T cells declines with age whereas the percentage of memory T cells increases (Linton and Dorshkind, 2004; Nikolich-Zugich, 2008).”
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age (2011, background): “In humans, age-associated hematopoietic changes include decreased bonemarrow cellularity (14), declines in lymphopoiesis (7, 15, 16), red cell abnormalities such as anemia (17), and increases in the incidence of myelodysplastic syndromes, myeloproliferative disorders, and myeloid malignancies (18).”
Causes, consequences, and reversal of immune system aging. (2013, neutral): “In contrast, primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8–10).”
Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010, positive): “There is decreased competence in the innate immune system (decreased natural-killer activity, decreased phagocytic ability of neutrophils and macrophages, and a pro-inflammatory state) and the adaptive immune system (decreased numbers of naive B and T cells, and increased numbers of memory B and T c”
How stem cells age and why this makes us grow old (2007, background): “Several effects of ageing on the blood organ are described in humans: decreased immunit”
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, background): “PLK2 inactivation was shown to extend the length of the cell cycle and delayed the entry into S phase (Ma et al. 2003), suggesting that PLK2 up-regulation in old LTHSCs could facilitate rapid progression through G1.”
Stems cells and the pathways to aging and cancer. (2008, background): “The most clinically significant of these changes are the decreased competence of the adaptive immune system (Linton and Dorshkind, 2004), the increased incidence of myeloid diseases including leukemias (Lichtman and Rowe, 2004), and the onset of anemia in the elderly (Beghe et al., 2004).”
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (2006, background): “The results of this study might partially explain the age-related loss of certain cognitive activities by viewing the decline in terms of an aging immune syste”
Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “Several reasons may account for this decline of thymic output: the direct infection of the thymic stroma and thymocytes by HIV [81,82]; and the atrophy of the thymus in HIV-infected subjects, which is similar to age-related ‘thymic involution’ [83] and may be related to thymosuppressive effects of p”