Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

By Yaniv Ziv, Noga Ron, O. Butovsky, G. Landa, E. Sudai, N. Greenberg, Hagit Cohen, Jonathan Kipnis, M. Schwartz. 2006

1,179 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Neurology

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In one study, the activation of microglia and recruitment of T cells were suggested to be required for enriched environment-induced SGZ neurogenesis (Ziv et al., 2006).”
The therapeutic potential of neural stem cells (2006, background): “In immune-deficient mice, hippocampal neurogenesis is markedly impaired and can be restored by T cells reacting against brain autoantigens (such as myelin basic protein, MBP”
Microglia: active sensor and versatile effector cells in the normal and pathologic brain (2007, background): “Sixth, protective potential and neurogenesis supported by microglia can be assisted by immune-associated mechanisms (that is, local interactions between microglia and T cells; see also ref”
The role of immune dysfunction in the pathophysiology of autism (2011, positive): “Exciting findings from animal models suggest that neurogenesis is modulated by the interaction between T cells and CNS cells (Ziv et al., 2006; Ziv and Schwartz, 2008).”
FAD-linked human Presenilin 1 variants impair environmental enrichment-induced hippocampal neural progenitor cell proliferation and differentiation in a non-cell-autonomous manner (2008, positive): “FAD-Linked PS1 Mutant Mice Fail to Exhibit High Activity-Induced Increases in Microglial Cell Numbers Recent studies have revealed a pivotal role for microglia in activation and maintenance of adult hippocampal neurogenesis in rodents following exposure to EE conditions (Ziv et al., 2006).”
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “…with the systemic immune system (Hanisch and Kettenmann, 2007; Louveau et al., 2015; Quan and Banks, 2007; Schlegelmilch et al., 2011; Schwartz and Shechter, 2010; Sierra et al., 2014; Tremblay 1276 Cell 169, 1276–1290, June 15, 2017 ª 2017 Elsevier Inc. et al., 2011; Ziv et al., 2006).”
Microglia regulate the number of neural precursor cells in the developing cerebral cortex (2013, background): “essary for neurogenesis in the adult hippocampus (Ziv et al., 2006); and that microglia phagocytose newly born neurons in the adult hippocampus (Sierra et al.”
Microglia: new roles for the synaptic stripper. (2013, positive): “Hippocampal neurogenesis induced by an exposure to the enriched environment was associated with the recruitment of T cells and the activation of microglia (Ziv et al., 2006), which further supports the facilitating role of microglia.”
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “Furthermore, CNS-specific T cells can provide neurotrophic factors such as BDNF and contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (Ziv et al., 2006).”
Neuroinflammation: The Devil is in the Details (2016, positive): “There is also evidence that immune cells, especially T-cells, communicate to resident cells and are critical to normal memory and learning processes (Ziv et al. 2006; Kipnis et al. 2012).”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, positive): “The influence of microglia on neurogenesis may be related to their interactions with T cells, since in transgenic mice with excess CNS-specific T cells the increased neurogenesis was attenuated by chronic treatment with the microglial inhibitor minocycline (Ziv et al., 2006).”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “Although this may seem surprising as non-noxious treatments such as environmental enrichment can influence microglial number and activation (Ziv et al., 2006), we were unable to find previous reports that ECS influences brain inflammation.”