A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

By S. Bultman, T. Gebuhr, D. Yee, C. Mantia, J. Nicholson, A. Gilliam, F. Randazzo, D. Metzger, P. Chambon, G. Crabtree and 1 more. Molecules and Cells, 2000

856 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/bb0bf5ddc86151a23e05a9f42e97c2ce8f3f0f85

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In Immunology

1. Tom Misteli
2. Stuart H. Orkin
3. J. Campisi

In Molecular Biology

1. Stuart H. Orkin
2. Tom Misteli
3. M. Mahalingam
4. Thomas R. Gingeras
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In Pathology and Forensic Medicine

1. Peter A. Jones

Citations in the corpus

• How is pluripotency determined and maintained? (2007, background): “5-6.0 Defective Not viable (F9 EC cells) NT NT NT Bultman et al., 2000; Sumi-Ichinose et al., 1997 Snf2h (Smarca5) Die at E4.”
• Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. (2008, positive): “ChIP experiments revealed that following addition of rIGFBP7, SMARCB1 as well as BRG1, an essential subunit of the SWI/SNF complex (Bultman et al., 2000), were recruited to the BNIP3L promoter near the transcription start site (Figure 3G).”
• ATP-dependent chromatin remodeling during mammalian development (2016, background): “Both Brg1 and Baf155 heterozygous mutants exhibit neural tube closure defects and exencephaly, suggesting that BAF complexes have an important and dosage-sensitive role in neural differentiation and development (Bultman et al., 2000; Kim et al., 2001).”
• The SWI/SNF complex — chromatin and cancer (2004, background): “Much like Snf5 -deficient mice, Brg1 −/− mice die at the blastocyst stage of early embryonic developmen”
• An essential switch in subunit composition of a chromatin remodeling complex during neural development. (2007, background): “Mice heterozygous for either Brg or BAF155/Srg3 are predisposed to exencephaly, possibly by generation of too few neurons (Bultman et al., 2000; Kim et al., 2001).”
• Global transcription in pluripotent embryonic stem cells. (2008, background): “A critical role for chromatin remodeling complexes in ES cell differentiation has been hinted at by the observation that disruption of several of these proteins, including Brg1 (Bultman et al., 2000; Bultman et al., 2006), Snf5 (Klochendler-Yeivin et al.”
• The SWI/SNF complex and cancer (2009, background): “Biallelic knockout of BRG1 is embryonically lethal (Sumi-Ichinose et al., 1997) (Bultman et al., 2000), and until recently it has been impossible to determine the effects of BRG1 silencing in tumorigenesis.”
• SWI/SNF nucleosome remodellers and cancer (2011, background): “In mice, Brg1 heterozygosity results in mammary tumours in 10% of the mice and the second Brg1 allele is always retained, indicating that Brg1 haploinsufficiency can drive tumorigenesi”
• Chromatin in pluripotent embryonic stem cells and differentiation (2006, background): “and the genomic disruption of chromatin-remodelling proteins, including BRG1 (Ref”