The SWI/SNF complex — chromatin and cancer

By C. Roberts, Stuart H. Orkin. Nature Reviews. Cancer, 2004

621 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c1f42dc5fb28da42b908f56864043c1f01c24cdd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Peter A. Jones
2. J. You
3. S. Baylin
4. Trey Ideker
5. Janusz Dutkowski

In Molecular Biology

1. Peter A. Jones
2. S. Baylin
3. J. You
4. Janusz Dutkowski
5. Trey Ideker
6. Xiaohua Shen
7. Cedric R Clapier
8. M. Lemieux

In Pathology and Forensic Medicine

1. Peter A. Jones
2. J. You
3. S. Baylin

Citations in the corpus

• The epigenomics of cancer. (2007, background): “Mutations in the SNF5 gene stimulate cell-cycle progression and cooperate with p53 loss in oncogenic transformation, and they are also associated with inactivation of the p21 and p16 pathways (Chai et al., 2005; Roberts and Orkin, 2004).”
• Protein Networks as Logic Functions in Development and Cancer (2011, background): “For example the core subunit of the complex, SNF5, is inactive in malignant rhabdoid tumors, a highly aggressive cancer of early childhood [11].”
• The biology of chromatin remodeling complexes. (2009, background): “Furthermore, Snf5-/- mice develop aggressive cancers that resemble human MRTs, and mSNF5 is involved in multiple processes involving genome stability and cell cycle control (182).”
• The SWI/SNF complex and cancer (2009, background): “However, loss of BAF47 appears to be a very rare event in human tumors (Roberts and Orkin, 2004).”
• Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Tumor suppressor properties of BRG1 and BRM have been reported in lung, breast, and prostate cancer cell lines (Roberts and Orkin, 2004) and, in vitro, BRG1 and BRM have been observed to interact with several tumor suppressors including BRCA1(Wang et al.”
• EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “Coexisting canonical EZH2- and noncanonical EZH1-mediated PRC2 complexes are analogous to the SWI/SNF chromatin remodeling complex mediated by BRG1 or BRM, two mutually exclusive ATPase subunits (Roberts and Orkin, 2004).”
• Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, positive): “…evidence raises the possibility that SWI/SNF complexes have a more widespread role in preventing tumorigenesis as specific mutations of this complex have been identified in cancers of the lung, breast, prostate, and pancreas (Roberts and Orkin, 2004; Medina et al., 2008; Reisman et al., 2009).”