An essential switch in subunit composition of a chromatin remodeling complex during neural development.
By Julie Lessard, Jiang I Wu, J. Ranish, Mimi Wan, M. Winslow, Brett T. Staahl, Hai-yin Wu, Ruedi Aebersold, Isabella A. Graef, Gerald R. Crabtree. Neuron, 2007
739 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c8b368d6366415c45c6e7403fb98cee60e016e2b
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In Molecular Biology
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Citations in the corpus
- EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “For example, a switch in BAF45 and BAF53 subunit composition of the SWI/SNF complex is required for proliferating neural stem cells transiting into postmitotic neurons (Lessard et al., 2007).”
- The biology of chromatin remodeling complexes. (2009, background): “during the transition from neural progenitors to postmitotic neurons: BAF45a and BAF53a are present only in progenitors and exchanged for BAF45b and BAF53b in postmitotic neurons (9) (Figure 5).”
- Protein Networks as Logic Functions in Development and Cancer (2011, background): “The neuronprogenitor version (npBAF) contains both BAF155 and BAF170 and also incorporates BRM and BAF60C while excluding BAF60B [10].”
- ATP-dependent chromatin remodeling during mammalian development (2016, background): “5 Post-natal BAF45A, BAF53A, SS18 9.5 10 10.5 11 11.5 12 12.5 13 13.5 ≥ P20 BAF45B, BAF45C, BAF53B and CREST Neural tube closure BAF subunit switch BRG1, BAF170 Gliogenesis BAF53 Dendrite development BAF170 SNF2H, CECR2 Neural maturation BRG1, BAF155 CECR2 CHD4 Parallel fiber/Purkinje cell synapsis ”
- Chromatin remodelling during development (2010, neutral): “Several subunits are encoded by gene families (for example, BRG1 and BRM are encoded by one gene family, and only one of these is present in each complex), giving rise to a diversity of stable assemblies that differ between cell types and that have distinct function”