SWI/SNF nucleosome remodellers and cancer

By B. Wilson, C. Roberts. Nature Reviews. Cancer, 2011

1,249 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/bfd714fe2644b42b4404355913bda1e8364c9f9b

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Citations in the corpus

Targeting EZH2 methyltransferase activity in ARID1A mutated cancer cells is synthetic lethal (2015, neutral): “nature medicine advance online publication PI3K–AKT signaling20,21; (2) PI3KCA is often mutated in OCCC, and mutations in PI3KCA and ARID1A often coexist in OCCC22,23; and (3) PIK3IP1 negatively regulates cell proliferation and promotes apoptosis20, the phenotypes observed in GSK126-treated ARID1A-”
Comprehensive Molecular Characterization of Human Colon and Rectal Cancer (2012, background): “Onofrio(4), Andrew Crenshaw(4), Kristin Ardlie(4), Rameen Beroukhim(4,13), Wendy Winckler(4), Gad Getz(4), Matthew Meyerson(4,13,14), Brigham and Women’s Hospital and Harvard Medical School – Alexei Protopopov (15), Juinhua Zhang (15), Angela Hadjipanayis (16,17), Eunjung Lee (17,18), Ruibin Xi (18)”
Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “…ARID1A, SMARCA4 (BRG1) and SMARCB1 (INI1) are associated with multiple types of cancer (Dawson and Kouzarides, 2012; Hargreaves and Crabtree, 2011; Tsai and Baylin, 2011; Wilson and Roberts, 2011), suggesting that defects in mobilizing nucleosomes near the promoters of active genes are involved.”
Cancer epigenetics: from mechanism to therapy. (2012, background): “motility, and nuclear hormone signaling (Wilson and Roberts, 2011).”
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 (2013, background): “Of the ATP-dependent chromatin remodelers, switch/sucrose nonfermentable (SWI/ SNF) complexes are emerging as bona fide tumor suppressors, as specific inactivating mutations in several SWI/SNF subunits are found in human cancers (9).”
DNA replication stress as a hallmark of cancer. (2015, background): “Gene expression profiles, cell lineage specificity, and/or cell differentiation state might be affected (42).”
Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Mutations in SWI/SNF ATPase subunits BRG1 or BRM have been reported in several cancers including lung, medulloblastoma, rhabdoid, and prostate tumors (Wilson and Roberts, 2011).”
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules (2012, background): “Furthermore, as mutations in chromatin remodeling complexes are becoming increasingly as- sociated with cancer (Wilson and Roberts 2011), whole-genome NOMe-seq is an ideal approach to address the effects that these mutations have, both on nucleosome positions and DNA methylation, and can further…”
MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS (2012, background): “…chromatin-remodelling complex were also mutated in our cohort, including significant recurrent mutations of SMARCA4(Brg/BAF190) , which encodes a DNA helicase with ATPase activity 13 and has been reported to be mutated in lung, ovarian, and pancreatic cancers 14 as well as medulloblastoma 15 .”