The impact of O2 availability on human cancer

By Jessica A. Bertout, Shetal A. Patel, M. C. Simon. Nature Reviews. Cancer, 2008

1,373 citations recorded by the source corpus.

Subfields: Cancer Research, Hepatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ba919598701ac73a20386e5c516b8a70788fe750

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. V. Vander Heiden
2. Craig B. Thompson
3. Jie Zheng
4. G. Semenza
5. Patrick S. Ward
6. Stephanie Alexander
7. D. Y. Gui
8. T. Mak

In Hepatology

1. Peter Friedl
2. Stephanie Alexander
3. V. Reddy Dondeti
4. M. Simon
5. J. Mazumdar

In Molecular Biology

1. M. V. Vander Heiden
2. Craig B. Thompson
3. Jie Zheng
4. Patrick S. Ward
5. Stephanie Alexander
6. D. Y. Gui
7. G. Semenza
8. T. Mak

Citations in the corpus

• Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “While cells in culture are exposed to atmospheric oxygen, oxygen availability in animal tissues is much lower (Bertout et al., 2008).”
• Hypoxia-inducible factors in stem cells and cancer (2009, positive): “Hypoxia was first correlated with tumour progression in the early 20th century, when researchers demonstrated increased tumour cell glycolysis in the presence of high O2 levels and the existence of a direct link between cellular hypoxia and radioresistance [1] (see timeline in [1]).”
• Mitochondrial Glutathione, a Key Survival Antioxidant (2009, background): “Hypoxia occurs in tissues when the availability of O2 is insufficient for the cellular demand, as happens in physiologic (embryonic development, exercising muscle) and pathologic conditions (stroke, tissue ischemia, inflammation, solid-tumor formation) (6, 116, 126, 132, 143).”
• Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “HIF1 is ubiquitously expressed in all cells, whereas HIF2 and HIF3 are selectively expressed in certain tissues (61).”
• Regulation of cancer cell metabolism (2011, background): “They are heterodimers that are composed of the constitutively expressed HIF1β (also known as ARNT) subunit, and either the HIF1α or the HIF2α (also known as EPAS1) subunits, which are rapidly stabilized on exposure to hypoxi”
• Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability (2011, background): “This question is particularly important given that many cancers and stem/progenitor cells can continue proliferating in the setting of limited oxygen availability (6, 7).”
• Understanding the intersections between metabolism and cancer biology (2017, neutral): “While oxygen is abundant in standard tissue culture, oxygen levels in even the best perfused tissues are 9% or less (Bertout et al., 2008), a value closer to the oxygen levels used to study hypoxia responses in culture.”