Mitochondrial Glutathione, a Key Survival Antioxidant

By M. Marí, A. Morales, A. Colell, C. Garcia-Ruiz, J. Fernández-Checa. Antioxidants and Redox Signaling, 2009

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The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “The mitochondria contain a separate pool of GSH that plays a key role in maintaining mitochondrial function (173).”
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, positive): “37 The member 39 in solute carrier family 25 (SLC25A39) acts as the mitochondrial transporter required for the import of mitochondrial GSH which can maintain the mitochondrial GSH concentration in mammalian cells.”
Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “[38] and readers are directed to this review for extensive details.”
ROS and ROS-Mediated Cellular Signaling (2016, background): “Besides, glutathione peroxidase (GPx), glutathione S-transferase pi (GST-pi), metallothionein-3 (MT3), ferritin heavy chain (FHC), and dihydrodiol dehydrogenase (DDH1 or AKR1C1) and so on also play decisive roles in the process of antioxidant [26–29].”