Understanding the intersections between metabolism and cancer biology

By M. V. Vander Heiden, Ralph J. Deberardinis. Cell, 2017

1,919 citations recorded by the source corpus.

Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress towards answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6210fad1bc6f3f6fef787bc3d5b4c5fff4465474

Citations in the corpus

• Lactate metabolism in human lung tumors (2017, neutral): “Accordingly, enhanced expression of glucose transporters and glycolytic enzymes is a common consequence of oncogenic signaling and transcriptional networks (Vander Heiden and DeBerardinis, 2017).”
• Mutant p53 as a guardian of the cancer cell (2018, neutral): “Reprogramming of cell metabolism is a hallmark of cancer, required to sustain tumor cells’ biosynthetic needs for continuous growth and proliferation [31].”