Hypoxia-inducible factors in stem cells and cancer

By J. Mazumdar, V. Reddy Dondeti, M. Simon. Journal of Cellular and Molecular Medicine, 2009

1,255 citations recorded by the source corpus.

• Introduction • From metabolic adaptation to stem cell signalling • HIF‐1α regulates Notch effects on cellular differentiation • Stem cell pluripotency requires HIF target gene function • O2 regulation of Wnt signalling is differentiation‐stage specific • HIFs, stem cell pathways and disease • HIF and cMyc • HIF and p53

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/7be44fffc252554df85f81eb15d3e0728d030bec

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Citations in the corpus

HUMAN VIRAL ONCOGENESIS: A CANCER HALLMARKS ANALYSIS (2014, background): “In hypoxia, stem-like and progenitor cells survive and expand (Keith and Simon, 2007), and may form carcinoma in situ.”
Hypoxia-induced angiogenesis: good and evil. (2011, background): “These observations demonstrate that hypoxia is not always a pathological entity and there is increasing evidence that it is an important component of some cellular niches, particularly those of stem and progenitor cells.(8) Nonetheless, low O 2 and its molecular sequelae play a critical role in the ”
Transcriptional Regulation by Hypoxia Inducible Factors (2013, methodology): “For a more in-depth perspective, we refer readers to several other reviews of the HIF transcriptional program (Keith & Simon, 2007; Tsai & Wu, 2012; Wenger et al., 2005).”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “The stem cell-like state ismediated by upregulation of OCT4, Notch, c-Myc, and telomerase (Keith & Simon, 2007).”
Translational regulation of gene expression during conditions of cell stress. (2010, background): “Perhaps the most important protein regulators of the hypoxic response are the hypoxia-inducible factors (HIFs) (Keith and Simon, 2007).”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “…subunits are classically known to be stabilized under low oxygen tensions; however, there is considerable evidence that HIF activation is deployed by many oncogene and tumor suppressor gene pathways that rely on increasing the protein’s synthesis or promoting its stability (Keith and Simon, 2007).”
Spherical Cancer Models in Tumor Biology (2015, background): “In general, the 3D local microenvironment in all spherical cancer models could enhance cell survival through strong cell – cell contacts and might, at least in the biggest ones, offer a hypoxic microenvironment favorable to cancer stemness [157].”
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “Developing mouse embryos contain regions that are profoundly hypoxic (Lee et al., 2001), whereas studies in cell culture reveal that HIFa inactivation has profound effects on cellular differentiation even in the presence of oxygen (Cowden Dahl et al., 2005; Keith and Simon, 2007).”
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α (2009, background): “At 1% oxygen condition, HIF-1a was observed within 2 h. Interestingly, there was no difference in HIF-2a expression.”
FoxO3 regulates neural stem cell homeostasis (2009, positive): “The finding that FoxO3 is required for the expression of genes that mediate the response to hypoxia in NSCs is consistent with the observation that hypoxia and HIF1 promote self-renewal and multipotency in stem cells (Keith and Simon, 2007).”