IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes1

By K. Boniface, F. Bernard, Martine Garcia, A. Gurney, J. Lecron, F. Morel. Journal of Immunology, 2005

882 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b9979437ba2d9745dcf40405ba8d86752ad1f2fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. M. Suárez‐Fariñas
2. J. Krueger

In Immunology

1. R. Flavell
2. Shomyseh Sanjabi
3. M. Suárez‐Fariñas
4. P. Murray
5. M. Collins
6. J. O’Shea
7. J. Krueger
8. Shizuo Akira

In Molecular Biology

1. Shomyseh Sanjabi
2. P. Murray
3. R. Flavell
4. J. O’Shea

Citations in the corpus

• Progressive activation of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis (2012, methodology): “%] in chronic AD skin) are within the psoriasis field, with few exceptions, including S100A7 and S100A8, which are synergistically induced by IL-17 and IL-22.”
• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “Moreover, they cause an increase in cytokine, chemokine, and IgE production leading to the exacerbated inflammatory reactions of atopic dermatitis.(297)”
• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “Moreover, IL-22 also stimulates proliferation, abnormal differentiation, and migration of various epithelial cells in vitro (Boniface et al., 2005; Brand et al., 2006; Sa et al., 2007).”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “Stimulation of keratinocytes with IL-22 leads to induction of the proinflammatory molecules such as S100A7 (also termed psoriasin) that promote psoriasis, as well as induction of antimicrobial peptides such as b-defensin [48,53].”
• Th17 cells in human disease (2008, background): “IL-22 is elevated in blood of patients with psoriasis (47), and IL-22R, which is expressed on epithelial cells, regulates proliferation and differentiation of keratinocytes (46).”
• Cytokine signaling modules in inflammatory responses. (2008, background): “…square with skin-inflammation models in which a pro-inflammatory role of IL-22 has been described by multiple laboratories (Boniface et al., 2005; Boniface et al., 2007; Ma et al., 2008; Wolk et al., 2004; Zheng et al., 2007), and recent studies that show protective roles of IL-22 in mucosal…”
• Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007, background): “However, other data suggest that IL-22 has a less direct inflammatory role and instead induces expression of genes associated with antimicrobial defense and cellular differentiation (Boniface et al., 2005; Wolk et al., 2004, 2006).”