The JAK/STAT signaling pathway: from bench to clinic

By Xiaoying Hu, Jing Li, Maorong Fu, Xia Zhao, Wei Wang. Signal Transduction and Targeted Therapy, 2021

2,213 citations recorded by the source corpus.

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.

Subfields: Epidemiology, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/119253a6c8ed65f213a82c6126f4ceec464c7402

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Zhao Huang
2. Yunhan Tan
3. Zhihan Wang
4. Bowen Li
5. Edouard C. Nice
6. Jing Tang
7. Mengtong Xu
8. Siyuan Qin

Citations in the corpus

• Oral squamous cell carcinomas: state of the field and emerging directions (2023, background): “69,115 Upregulated STAT3 is associated with HNSCC malignancies and resistance to chemotherapy, radiotherapy, and EGFR-targeted therapy.”