The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
By A. Gartel, A. Tyner. Molecular Cancer Therapeutics, 2002
1,003 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/b5deec2125724014c605b3c46cd626ac96bb081c
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Citations in the corpus
- Senescence and apoptosis: dueling or complementary cell fates? (2014, unknown): “p21 expression has been proposed to negatively regulate p53dependent apoptosis [69].”
- Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. (2007, background): “The PTH-stimulated increase in p21Cip1 that contributes to the increase in Runx2 may also have a separate pro-survival effect as p21Cip1 can prevent activation of caspases and block the pro-apoptotic effects of apoptosis signal-regulating kinase 1 [59].”
- The Role of Resveratrol in Cancer Therapy (2017, background): “, WAF1/CIP1 encoding for p21, which belongs to the group of CDK inhibitors that are vital to the inhibition of cell growth [87].”
- Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. (2009, background): “The N-terminal regions are well conserved among the three members, including the cyclin/CDK-binding motifs (Gartel and Tyner, 2002).”
- Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011, background): “As a target of p53-mediated cell cycle arrest and apoptosis (Gartel & Tyner 2002), p21 promotes cell survival in response to oxidative stress (O’Reilly 2005).”
- The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “In addition to promoting cell cycle arrest, p21 is also involved in other cellular processes including senescence, apoptosis and the response to oxidative stress (Esposito et al. 1998; Gartel and Tyner 2002; Abbas and Dutta 2009).”
- When NRF2 Talks, Who's Listening? (2010, unknown): “p21 is involved with many different cellular processes, including cell-cycle arrest, cell differentiation, senescence, apoptosis and DNA replication and repair, and oxidative stress (29, 31, 38, 86, 107).”