Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.

By S. Ashkar, G. Weber, Vassiliki Panoutsakopoulou, M. Sanchirico, M. Jansson, S. Zawaideh, S. Rittling, D. Denhardt, M. Glimcher, H. Cantor. Science, 2000

1,185 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Rheumatology

View Paper: https://www.semanticscholar.org/paper/b41587b9908d46b5ada30435891a996b51757766

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. E. Wherry
2. Rafi Ahmed
3. L. Sorokin
4. A. Tedgui
5. Z. Mallat
6. Pengfei Lu
7. D. Scadden
8. S. Kaech

In Immunology and Allergy

1. Pengfei Lu
2. Rafi Ahmed

In Rheumatology

1. Pengfei Lu
2. E. Wherry

Citations in the corpus

• Aldosterone induces a vascular inflammatory phenotype in the rat heart. (2002, background): “in macrophages (2) and in T cells (20) and has been”
• The impact of the extracellular matrix on inflammation (2010, background): “In addition, osteopontin stimulates IL-2 secretion, which is required for T cell survival, and simultaneously inhibits apoptosis of effector T cells, thereby enhancing the survival of autoreactive T H 1 and T H 17 cells in the CN”
• Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size (2005, background): “For example, granulomatous responses are associated with high levels of OPN expression (16, 17, 20) and OPN can function as a Th1 cell cytokine, enhancing IL-12 while inhibiting expression of the Th2 cell cytokine IL-10 (17, 19, 21).”
• Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. (2001, background): “OPN is expressed in human and murine granulomatous responses of diverse etiology (15, 16), and work with OPN-null mice suggests that this protein is required for functional granuloma formation.”
• Extracellular matrix: a dynamic niche component during cancer progression (2012, positive): “For example, increased ECM stiffness can promote integrin mediated adhesion complex assembly and activate T cells (Ashkar et al., 2000; Adler et al., 2001; Hur et al., 2007; Sorokin, 2010).”
• Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment (2003, background): “Further, CD44 can bind soluble factors, such as osteopontin (8, 14), and since its intracellular domains can associate with signaling molecules, it may transduce signals about the extracellular environment or act as a costimulatory molecule (14).”
• The stem-cell niche as an entity of action (2006, background): “Implicated previously in tumour metastasis and cell-mediated immunit”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “OPN, also known as Eta-1 (early T lymphocyte activation 1), is a pleiotropic cytokine critical for the generation of Th1 immunity (29).”
• Lineage commitment in the immune system: the T helper lymphocyte grows up. (2000, background): “The mechanism by which this occurs remains unclear because the APC counterpart cytokine of IL-12 for Th2 differentiation is not known, although IL-6 has been suggested as a candidate (Rincon et al. 1997).”
• CD4+T Cells: Differentiation and Functions (2012, background): “Lineage-specific differentiation depends on the cytokine milieu of the microenvironment, as well as on the concentration of antigens, type of APCs, and costimulatory molecules [11, 12].”