Extracellular matrix: a dynamic niche component during cancer progression

By Pengfei Lu. 2012

2,966 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/3fca40f6a3c524e3208a0f95c34cd67f453bae03

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In Immunology and Allergy

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Citations in the corpus

Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “able to influence various anchorage-related biological functions, like cell division, tissue polarity and cell migration [6].”
Extracellular matrix structure. (2016, background): “9 within the tumor stroma, such as cancer-associated fibroblasts, endothelial cells, immune cells, pericytes, but also tumor cells themselves, participate in the formation of deregulated and disorganized ECMs that favor and promote tumorigenesis [12].”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “The ECM, which is jointly produced and deposited in the extracellular space by tumor cells and host cells, undergoes profound changes in composition, structure, and mechanical properties during tumor progression (Lu et al., 2012).”
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Meanwhile, cell-to-cell activity residing in the TME is constantly reshaping ECM, and these cells are affected by the signals provide by ECM itself [13].”
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “Enhanced production and reorganization of the ECM leads to a mechanically stiff microenvironment, which has been shown to promote tumor cell proliferation and invasion as well as changes in gene expression and behavior of stromal cells, thereby enhancing tumor progression (113, 124, 125).”
Targeting cancer stem cell pathways for cancer therapy (2020, methodology): “used to aggregate CSCs(514) and induce drug resistance.(513,515) Fibronectin, vimentin, collagen, and proteoglycan in the ECM bind to cytokines such as FGF, HGF, VGF, BMP, and TGF-β in the TME and regulate their activities.”