Cytokines in atherosclerosis: pathogenic and regulatory pathways.

By A. Tedgui, Z. Mallat. Physiological Reviews, 2006

1,764 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/34f7738fd7280f306061d06765ab04e665ab6bff

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Citations in the corpus

Inflammatory Cytokines in Vascular Dysfunction and Vascular Disease (2009, background): “Macrophages also express a number of chemokines such as MCP-1/CCL2, MCP-4/CCL13, and IL-8/CXCL8 [7].”
Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice (2008, result): “Discussion The present study presents 3 major findings: (1) Combined activation of CCL2, CX3CR1, and CCR5 pathways accounts for most of the macrophage accumulation within atherosclerotic lesions; (2) CCL2, CX3CR1, and CCR5 markedly and differentially alter the number of monocyte subsets within the b”
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment (2007, background): “An impressive body of evidence supports the concept that atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by an influx of immunocompetent mononuclear cell”
Inflammatory caspases and inflammasomes: master switches of inflammation (2007, background): “may contribute to the pathogenesis of arteriosclerosis in different ways, including by promoting coagulation and thrombosis.(22,23) Importantly, IL-1b was shown to control”
Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes (2014, background): “A broad spectrum of cytokines and chemokines has been implicated to play a role in atherogenesis, including IL-6, IL-18, TNFα, monocyte chemoattractant protein 1 (MCP-1), and IL-8.(19) To study the effect of brief exposure of oxLDL on the production of these cytokines and chemokines, monocytes were ”
Origin and physiological roles of inflammation (2008, result): “This idea is in accordance with the fact that many inflammatory mediators (including TNF-α, IL-6, CCL2 and prostaglandins) also have important homeostatic functions, for example in repair of tissues, control of metabolism, and regulation of the hypothalamus–pituitary axi”
The immune system in atherosclerosis (2011, background): “However, T cells are activated in lesions, produce proatherogenic mediators and contribute to lesion growth and disease aggravatio”
Cardiovascular actions of insulin. (2007, background): “cells that has been implicated in insulin resistance (333, 334).”
Smooth muscle cell phenotypic switching in atherosclerosis. (2012, background): “We do not refute the well-established dogma that an increase in the ratio of macrophages to SMC within lesions is causally linked to plaque destabilization as stated repeatedly in major reviews in the field.(26,55) However, given the uncertainties in identification of cells within lesions already di”
Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation (2010, background): “Once activated, the monocytes and macrophages secrete a myriad of cytokines that promote inflammation in the arterial wall [2], yet the factors that trigger and maintain this cytokine release in atherogenesis are not fully understood.”