Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

By Masayuki Tsuji, N. Komatsu, Shimpei Kawamoto, Keiichiro Suzuki, O. Kanagawa, Tasuku Honjo, S. Hori, S. Fagarasan. Science, 2009

628 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b29aa163b027ae644b47d9d388be7827aea17d14

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In Immunology

1. Dan R. Littman
2. K. Honda
3. W. E. Paul
4. Jinfang Zhu
5. Jacques Banchereau
6. Y. Belkaid
7. D. Campbell
8. M. Koch

Citations in the corpus

• CD4+T Cells: Differentiation and Functions (2012, background): “FoxP3+Treg in Peyer’s patches differentiated into Tfh, with subsequent interaction with B cells and production of Ig A [112].”
• Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis (2009, background): “Moreover, transferred T reg cells can generate follicular helper T cells in the Peyer's patches under the influence of CD40 expression by B lymphocyte”
• Role of the Microbiota in Immunity and inflammation (2014, background): “…with the induction of oral tolerance, commensalspecific Treg can promote class switching to IgA in an antigenspecific manner (Cong et al., 2009; Tsuji et al., 2009), thereby controlling the host relationship with the microbiota via multiple mechanisms (Peterson et al., 2007; Suzuki et al.,…”
• Gut Microbial Metabolites Fuel Host Antibody Responses. (2016, background): “, 2011), some Tregs can convert to Tfh cells in PP (Tsuji et al., 2009).”
• The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “This is conceivable, in light of recent work suggesting there may be much more plasticity during T cell differentiation than was previously appreciated (Zhou et al., 2009; Tsuji et al., 2009).”
• Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “The fact that, in the gut, Tfh cells can be derived from Tregs, suggests effector Th cells may also acquire Tfh function (171).”
• Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Furthermore, mouse Th2 (Zaretsky et al., 2009) and Treg (Tsuji et al., 2009) cells were shown to be convertible into Tfh cells in vivo.”
• Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, result): “However, several studies have demonstrated that even thymic-derived T Reg cells can convert to an effector phenotype following transfer into lymphopenic recipient”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “Interestingly, a population of Foxp3+ Treg cells in the intestine loses the ability to express Foxp3 and becomes follicular helper T cells (Tfh cells) that interact with B cells and facilitate class switch recombination to IgA (218).”
• Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. (2012, background): “We argue that such superior population expansion of non-Treg cell-derived exFoxp3 T cells (and/or inferior population expansion of Treg cells), rather than Treg cell reprogramming, accounts for the plasticity of Foxp3 T cells observed in a range of other conditions (Murai et al., 2009; Tsuji et al.,”