Gut Microbial Metabolites Fuel Host Antibody Responses.

By Myunghoo Kim, Yaqing Qie, Jeongho Park, Chang H. Kim. Cell Host and Microbe, 2016

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Metabolic Instruction of Immunity (2017, positive): “…gut The metabolic relationship between commensals and immune cells in the gut is further illustrated by the finding that SCFAs derived from the fermentation of dietary fiber by gut microbiota promote B cell metabolism and boost antibody responses in both mouse and human B cells (Kim et al., 2016).”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Arpaia et al., 2013; Brown et al., 2003; Chang et al., 2014; Donohoe et al., 2012; Kalina et al., 2002; Kim et al., 2016; Le Poul et al., 2003; Macia et al., 2015; Maslowski et al., 2009; Millard et al., 2002; Nilsson et al., 2003; Singh et al., 2010; Smith et al., 2013; Thangaraju et al., 2009a,…”
SCFA: mechanisms and functional importance in the gut (2020, background): “Dietary fibres and SCFA enhance antibody response to bacteria by supporting B cell differentiation into plasma B cells via the increase of histone acetylation and of B cell metabolism((161,162)).”
Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism (2018, background): “Acetyl-CoA produced during FAO can then fuel the OXPHOS and glycolytic pathways (Kim et al., 2016; Nsiah-Sefaa and McKenzie, 2016; van der Windt et al., 2012).”