Translating stem and progenitor cell biology to the clinic: barriers and opportunities.

By Irving L. Weissman. Science, 2000

889 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b0e40bf120c914a9443277a9c3779193823706fc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Daniel J. Garry
2. T. Hawke
3. P. Robey
4. P. Bianco
5. Fred H. Gage
6. Stuart H. Orkin
7. Linheng Li
8. T. Xie

In Molecular Biology

1. S. Morrison
2. M. Clarke
3. Linheng Li
4. Irving L. Weissman
5. Daniel J. Garry
6. T. Hawke
7. Fred H. Gage
8. Stuart H. Orkin

In Physiology

1. T. Xie
2. Linheng Li
3. Stuart H. Orkin
4. Fred H. Gage
5. P. Robey
6. T. Reya
7. P. Bianco
8. M. Lutolf

Citations in the corpus

• Stem cells, cancer, and cancer stem cells (2001, background): “Although the phenotypic and functional properties of HSCs have been extensively characterized (reviewed in ref”
• Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion (2002, background): “jpg" NDATA ITEM> ]> Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many other”
• Evidence that fibroblasts derive from epithelium during tissue fibrosis. (2002, background): “Unfortunately, the order and assembly of these patterned events are not well understood (4, 5); for that matter, not all cells have been studied.”
• Stem cell niche: structure and function. (2005, background): “They either are progressively restricted in development, giving rise to multiple lineages (including tissue-specific cells), or are unipotent, giving rise to single lineage cells destined for certain tissues (Fuchs et al. 2004, Rossant 2004, Weissman 2000).”
• Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005, background): “Although knowledge about signals and the underlying pathways regulating stem cell fate are being identified rapidly, significant technical obstacles need to be overcome before stem cells can be used efficiently and safely in the clini”
• Diversification of haematopoietic stem cells to specific lineages (2000, background): “The ability of HSCs to self-renew underlies bone marrow transplantation, a procedure of enormous clinical utilit”
• Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation (2001, methodology): “The development of hematopoietic assays for human stem cells permits the use of primary human cells as a model system to study human stem cell biolog”
• Mesenchymal stem cells: revisiting history, concepts, and assays. (2008, background): “…for which stem cell self-renewal is considered to be solidly proven is the hematopoietic system, based on the ability of phenotypically defined HSCs to serially reconstitute hematopoiesis for the lifetime of lethally irradiated mice (Osawa et al., 1996; Spangrude et al., 1988; Weissman, 2000).”
• Myogenic satellite cells: physiology to molecular biology. (2001, background): “Progenitor cells that are resident in other adult tissues have stem cell characteristics, as they are capable of self-renewal and multilineage differentiation along a specified molecular pathway (61, 194, 195).”