Diversification of haematopoietic stem cells to specific lineages

By Stuart H. Orkin. Nature reviews genetics, 2000

676 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Physiology

View Paper: https://www.semanticscholar.org/paper/baf1cf3eb2172596fd55d73ccc6327ff2501b5eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Daniel G. Tenen
2. Leonard I. Zon
3. T. Xie
4. Linheng Li

In Hematology

1. Daniel G. Tenen
2. Leonard I. Zon
3. Linheng Li
4. T. Xie

In Physiology

1. Daniel G. Tenen
2. Leonard I. Zon
3. T. Xie
4. Linheng Li
5. Stuart H. Orkin

Citations in the corpus

• Exponential scaling of single-cell RNA-seq in the past decade (2017, background): “Cells have traditionally been classified by their morphology or by expression of certain proteins in functionally distinct settings (Mosmann et al., 1986; Orkin, 2000; Poulin et al., 2016).”
• Stem cell niche: structure and function. (2005, background): “Bone marrow serves as the pioneer system for studying stem cells; the concept and basic features of stem cells were defined from studying hematopoietic stem cells (HSCs) (Orkin 2000, Till & McCulloch 1961, Weissman et al. 2001).”
• High-dimensional switches and the modeling of cellular differentiation (2004, neutral): “…of heterozygous and homozygous mutants, heterokaryon studies, or knock-down mutations (Weintraub, 1993, McDevitt et al., 1997, reviewed by Orkin, 2000; Crittenden et al., 2002), by monoallelic expression of a gene such as Pax5 (Nutt et al., 1999), and by dosage effects of interacting…”
• Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “The genes encoding the SET-domain containing histone methyltransferase MLL and runt-domain Runx1 proteins are essential for generation of HSCs within the AGM (and possibly at other sites) (Orkin, 2000).”
• Stepwise reprogramming of B cells into macrophages. (2004, neutral): “C/EBP (a maintained by a set of more than a dozen lineage- bZip family transcription factor) may also play a role in restricted transcription factors that are part of a “tran- B cell differentiation, since ablation of this factor, which scription factor network” (Orkin, 2000; Sieweke and is expresse”
• Disruption of differentiation in human cancer: AML shows the way (2003, background): “As described above, most patients with AML that have mutations in PU.1 or C/EBPα do not have chromosome translocations such as t(8;21), t(15;17) or Inv16.”
• A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling (2005, neutral): “specification [40].”