Mesenchymal stem cells: revisiting history, concepts, and assays.

By P. Bianco, P. Robey, P. Simmons. Cell Stem Cell, 2008

1,586 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/37d800c223aaf53b17e41eaa4d26defe2f0cfcc7

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In Biomaterials

1. D. Prockop
2. A. Caplan
3. J. Karp
4. Grace Sock Leng Teo

In Genetics

1. J. Karp
2. Grace Sock Leng Teo
3. A. Caplan
4. D. Prockop
5. A. Keating
6. Fanxin Long
7. H. Kronenberg
8. L. Meirelles

In Surgery

1. J. Karp
2. D. Prockop
3. Grace Sock Leng Teo
4. A. Caplan
5. A. Keating
6. R. Lee

Citations in the corpus

• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Demonstrating self-renewal of putative MSCs in vivo is technically difficult because the turnover rate of connective tissues is far lower than that of hematopoietic tissue [43].”
• Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro (2013, background): “For general information on the delicate differences between stem cells and the uncertainties about the definition of mesenchymal stem cells, please refer to the commentary of Bianco and colleagues [5].”
• Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. (2009, background): “Blood 110: 3499–3506. 9. Owen, M and Friedenstein, AJ (1988). Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 136: 42–60. 10. Friedenstein, AJ, Gorskaja, JF and Kulagina, NN (1976). Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4: 26”
• Mesenchymal stem cell homing: the devil is in the details. (2009, positive): “…may be derived from multiple tissues, it is critical to consider that significant phenotypic differences in MSCs exist which may reflect distinct functional properties (Bianco et al., 2008), and this heterogeneity may be a function of their tissue microenvironment (da Silva Meirelles et al., 2006).”
• Leptin Receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow (2014, neutral): “…as nonhematopoietic, plastic-adherent, col- ony-forming cells, referred to as colony-forming unit-fibroblasts (CFU-Fs), that can differentiate into osteogenic, chondrogenic, and adipogenic progeny (Bianco et al., 2008; Friedenstein et al., 1970; Horwitz et al., 2005; Pittenger et al., 1999).”
• Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “Differences in MSC isolation, culture, and experimental design (Bianco et al., 2008) have made it difficult to make broad conclusions regarding the role of hypoxia on the biology of MSCs.”
• Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “However, the exact identity of the cell populations enriched by these markers is the source of some debate — they are often called mesenchymal stem cells but may include both bona fide stem cells and more committed progenitors, and they are likely to differ depending on the markers being used; these”
• Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration (2012, background): “The Mx1-induced cells are predominantly osteolineage restricted with only a minimal amount of adipocytic cell marking with lineage tracing and are more consistent with a skeletal stem cell as proposed by Bianco et al. than a broadly defined MSC (Bianco et al., 2008).”
• Mesenchymal stromal cells: new directions. (2012, background): “There have been several comprehensive recent reviews on MSCs (Uccelli et al., 2008; Bianco et al., 2008; Tolar et al., 2010; Ranganath et al., 2012).”
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, positive): “Most likely, the ‘‘true’’ stem cells constitute only a subset of the bone marrow cell population, as selected by rapid plastic adherence, implying that this cell population is heterogeneously composed of bona fide stem cells, their progeny (with multilineage differentiation potential, but without sa”
• Control of stem cell fate by physical interactions with the extracellular matrix (2009, neutral): “stem cells (Bianco et al., 2008).”