Evidence that fibroblasts derive from epithelium during tissue fibrosis.

By M. Iwano, David Plieth, T. Danoff, Chengsen Xue, H. Okada, Eric G. Neilson. Journal of Clinical Investigation, 2002

2,078 citations recorded by the source corpus.

Subfields: Genetics, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/678e2c6c035a06005cf828f93dc794ddc035ecbb

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Citations in the corpus

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis (2007, background): “However, recent studies in organs such as the kidney, lung and liver and in metastatic tumors have shown that during fibrosis, in addition to the proliferation of resident fibroblasts, bone marrow–derived fibroblasts and epithelial cells contribute to fibroblast accumulation through an epithelial-me”
The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “…factors capable of triggering the EMT process (Nieto et al. 1994) as well as the cellular programs they control (Inukai et al. 1999, Vega et al. 2004) and the engagement of cancer and fibrosis as the dark side of the EMT (Batlle et al. 2000, Cano et al. 2000, Iwano et al. 2002, Moody et al. 2005).”
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology. (2016, background): “For example, in a model of tubulointerstitial renal fibrosis, the use of the promoter region of the gene encoding g-glutamyltranspeptidase, a proximal tubule marker, for cell lineage tracing suggests that 36% of renal fibroblasts derive through EMT from renal tubular epithelium (Iwano et al. 2002).”
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “s well as leucocytes Nucleus and/or cytoplasm [43,186]”
The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, methodology): “Kidney FSP1-positive cells derive from two sources; from the bone marrow and from an EMT at sites of renal fi brosis ( Iwano et al., 2002 ).”
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (2009, positive): “During renal fibrosis, renal epithelial cells are converted into myofibroblasts through a bona fide EMT (96).”
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy (2019, background): “Generally, epithelial and endothelial cells undergo epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT), respectively, with an expression of S100A4 (fibroblast specific protein-1, also called FSP-1) and adopt a fibroblastic phenotype [29, 30].”
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. (2007, background): “We previously reported that interstitial cells positive for fibroblast-specific protein–1 (FSP-1; also known as S100A4), which in part originate from renal epithelial cells through EMT, play an important role in the progression of renal fibrosis (20).”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “However, elegant cell tracing studies have shown that a significant portion of these myofibroblasts arise from the conversion of epithelial cells through an EMT process (Iwano et al., 2002).”
Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “Other examples of regulated EMT in the adult is placental formation (Vicovac and Aplin, 1996), and the production of fibroblasts during inflammation (Iwano et al., 2002) and wound healing (Desmouliere, 1995).”