Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

By M. Lutolf, J. Hubbell. Nature Biotechnology, 2005

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Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering (2010, background): “A number of cell lines have been explored to immobilize on bioactive PEG hydrogels, including fibroblasts, chondrocytes, vascular smooth muscle cells (SMCs) and endothelial cells (ECs), osteoblasts, neural cells, and stem cells [46,47].”
Cell–matrix adhesion (2007, background): “Elevating actomyosin contractility or endogenous tension induces cell-associated fibronectin to undergo a conformational change that reveals previously concealed fibronectin-binding sites and triggers fibronectin matrix assembly (Pankov and Yamada, 2002; Mao and Schwarzbauer, 2005).”
Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture (2009, background): “This allows the controlled placement of specific binding domains onto an otherwise bioinert background ( Lutolf and Hubbell, 2005 ) to study the interactions between adhesive peptide sequences, such as RGD and IKVAV, and cell function.”