Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

By N. Terada, T. Hamazaki, M. Oka, M. Hoki, Diana M. Mastalerz, Yuka Nakano, E. Meyer, L. Morel, B. Petersen, E. Scott. Nature, 2002

2,093 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e1d02e3b7ae152aa7eabea4f24d9b0fc5abdc425

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. S. Sell
2. Li Chai
3. Guido Kroemer
4. C. Hui
5. Diane S. Krause
6. Erica L Herzog
7. D. Lyden
8. P. Labosky

In Hepatology

1. G. Michalopoulos

In Molecular Biology

1. Guido Kroemer
2. Hynek Wichterle
3. M. Castedo
4. J. A. Porter
5. I. Lieberam
6. D. Lyden
7. Shahin Rafii
8. S. Sell

Citations in the corpus

• Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. (2004, background): “stem cell plasticity, including marrow stromal cells, raising questions about its mechanisms of transdifferentiation in vivo (27, 28).”
• Autologous mesenchymal stem cell transplantation in stroke patients (2005, background): “15 It is still controversial, however, whether spon-taneous cell fusion 18,19 or true differentiation 20,21 was the primary cause for these unexpected cell outcomes.”
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “Recent reports suggest that stem cells appear to “transdifferentiate” by cell fusion events that may lead to the detection of Y chromosome–positive cells within otherwise differentiated cells of a certain tissue (35, 36).”
• Cell fusion is the principal source of bone-marrow-derived hepatocytes (2003, background): “Two reports have raised the issue of whether fusion between donor haematopoietic cells and host hepatocytes could explain the apparent stem cell plasticit”
• Stem cell origin of cancer and differentiation therapy. (2004, background): “vitro culture of adult mouse brain or bone marrow stem cells with embryonic cells generates hybrid cells containing chromosomes of both adult and embryonic cells [220,221], thus raising the question of whether adult stem cells make other tissues by fusing with existing tissue cells.”
• Directed differentiation of embryonic stem cells into motor neurons. (2002, background): “Analysis of the Certain cell populations have been reported to undergo fusion with somatic cells (Terada et al., 2002; Ying pattern of peripheral projections of eGFP motor axons in stage 27 embryos revealed that HBG3 ES cell-derived et al., 2002) prompting us to test the possibility that HBG3 ES cel”
• Cell death by mitotic catastrophe: a molecular definition (2004, background): “Aneuploidization could result from the asymmetric division of polyploid cells, generated from an illicit cell fusion, as it may occur in vivo (DeWitt and Knight, 2002; Terada et al., 2002; Wurmser and Gage, 2002; Vassilopoulos et al., 2003) or from endoreplication/endomitosis (Nitta et al., 2003).”
• Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts (2003, background): “Although several investigators have claimed that these cells differentiate into cardiac myocytes, previous in vitro studies have shown that stem cells may fuse with existing native cell”
• A dermal niche for multipotent adult skin-derived precursor cells (2004, background): “Although some reported cases of multipotency are due to unanticipated cellular fusion event”
• Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity (2009, background): “Many studies have failed to document MSC differentiation into cardiac cell constituents in the infarcted heart (12, 28, 29).”