Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

By Matthew A. Williams, A. Tyznik, M. Bevan. Nature, 2006

875 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b0e14ad4ef6de9fea855adf665c884147a729961

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In Immunology

1. M. Bevan
2. Rafi Ahmed
3. E. Wherry
4. T. Malek
5. S. Kaech
6. V. Badovinac
7. J. Harty
8. I. Castro

Citations in the corpus

• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “Interestingly, IL-2 acts early during infection to instill robust recall capacity in the memory CD8+ T cells that develop later (Williams et al., 2006).”
• Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “Paracrine IL-2 produced by CD4 + T cells during the initial priming of CD8 + T cells in LCMV infection dramatically improves the CD8 + T cell recall response potentia”
• Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “…IL-7Ra and CD62L, and eventually become long-lived memory cells, whereas cells expressing higher numbers of CD25 molecules undergo more rapid proliferation, exhibit a terminally differentiated effector phenotype, and are eliminated by apoptosis (Kalia et al., 2010; Williams et al., 2006).”
• Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, background): “However, evidence exists in favor of both positive and negative impact of IL-2 on CD8 T cell memory development (Blattman et al., 2003; Cheng and Greenberg, 2002; Cheng et al., 2002; Williams et al., 2006).”
• Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, methodology): “Mice were infected with 2 3 105 PFU of LCMV-Armstrong intraperitoneally 10–12 weeks posttransplant.”
• T-cell quality in memory and protection: implications for vaccine design (2008, background): “And third, secretion of IL-2 promotes the expansion of T cells in an autocrine or paracrine manner, which could enhance CD8 + T-cell memory functio”
• IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “cells (Treg cells) to eliminate autoreactive T cells and promote self-tolerance [23], whereas IL-2 also promotes the differentiation of CD8 T cells into effector and memory cytolytic T lymphocytes (CTL) upon antigen stimulation [24 ,25 ,26].”
• CD4+T Cells: Differentiation and Functions (2012, background): “Besides its role as T cell growth factor, IL2 was also found to promote the development of CD8+ memory cells after antigen priming, and thus participating in ensuring a robust secondary immune response [123].”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “However, the Il2ra / memory CD8+ T cells failed to mount a response upon antigenic rechallenge (Williams et al., 2006).”
• Shaping and reshaping CD8+ T-cell memory (2008, background): “However, experiments with IL-2-deficient mice showed that this cytokine is not essential for apparently normal expansion and memory CD8 + T-cell generatio”
• CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “Clonal expansion is only slightly decreased in cells lacking CD25 but they show phenotypic and functional alterations (Bachmann et al., 2007; Obar et al., 2010; Williams et al., 2006).”
• Regulatory T Cells and Human Disease. (2020, background): “IL-2 deprivation can also be effective in suppressing NK cells and hampering secondary expansion of CD8+ memory T cells (62, 63).”