T-cell quality in memory and protection: implications for vaccine design

By R. Seder, P. Darrah, Mario Roederer. Nature reviews. Immunology, 2008

1,677 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b99a0b87d96cb149e869150b891afd3d1d5c77f6

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In Immunology

Citations in the corpus

Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “Secondary effector T cells The presence of memory CD4 + T cells that are capable of producing multiple cytokines has been correlated with superior protective capacity in numerous studie”
Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, background): “This property of T cells, distinct from their frequency (magnitude of the response) and phenotype has been referred to as the ‘‘quality’’ of the response (45).”
Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data (2015, background): “Polyfunctional T cells (2)—subsets of Ag-specific T cells that simultaneously produce multiple effector cytokines and other functional markers in response to activation—are believed to be of clinical relevance, and there is evidence linking their frequency to clinical outcome (3).”
Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “In summary, polyfunctional T cells appear to be optimized effector cells that are also in the pivotal differentiation stage between central and effector memory T cells (61).”
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, methodology): “We then stimulated the four T cell subsets and expanded them in vitro for 7 d; we then measured production of IL-22, IL-17 and IFN-γ by multicolor intracellular staining and analyzed the data with Boolean gatin”