CD8+ T Cells: Foot Soldiers of the Immune System
By Nu Zhang, M. Bevan. Immunity, 2011
1,066 citations recorded by the source corpus.
Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection. The initial interaction with antigen-presenting cells in the central lymphoid organs drives an orchestrated program of differentiation aimed at producing sufficient numbers of effectors to get the job done without resulting in clonal exhaustion. Interactions with antigen-presenting cells and other immune cells continue at the site of infection to regulate further on-site expansion and differentiation, all with the goal of protecting the host with minimal bystander tissue damage. Here we review recent advances in CD8+ T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8+ T cell expansion and differentiation are controlled in these contexts.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/87c900ee5e235c3052064ed00d8893f1b3c0358f
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Citations in the corpus
- Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “Nucleic acid detection can lead to the production of protective type I IFN via endosomal or cytoplasmic sensors (Barber, 2011; Desmet and Ishii, 2012; Zhang et al., 2011a; Zhang et al., 2011b).”
- Mechanisms controlling PD-L1 expression in cancer (2019, background): “However, hyperactivation of uncontrolled T cells may also attack normal cells (Zhang and Bevan, 2011).”
- Properties of MHC Class I Presented Peptides That Enhance Immunogenicity (2013, background): “Finally, an immune response might be outcompeted by other T-cell responses due to limited survival factors, a phenomenon called competitive exclusion [41,42].”