Improving the nutritional value of Golden Rice through increased pro-vitamin A content

By Jacqueline A Paine, C. Shipton, Sunandha Chaggar, Rhian M. Howells, Mike J Kennedy, G. Vernon, S. Wright, E. Hinchliffe, Jessica L Adams, A. Silverstone and 1 more. Nature Biotechnology, 2005

1,356 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ae640f5fcc7f02e87afd8a9e6e8d34113d3d7bf2

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Citations in the corpus

Genetically Modified Rice Adoption: Implications for Welfare and Poverty Alleviation (2004, background): “The Basel-based biotech giant Sygenta, has recently announced Golden Rice 2, which is said to have more than 20 times total carotenoids of the original variety and so could provide as much as half the recommended daily allowance of Vitamin A, depending on the availability of complementary proteins a”
Economics of biofortification (2007, neutral): “A case in point is Golden Rice: biotechnologists managed to produce a transgenic rice line containing up to 31 µg/g of beta-carotene in the endosperm (Paine et al., 2005).”
Carotenoid biotechnology in plants for nutritionally improved foods (2006, methodology): “Overexpression of the monocot PSY together with the bacterial desaturase encoded by crtI in the endosperm of the grain was shown to boost the production of carotenoids, reaching up to 37 mg g 1 dry weight (Paine et al. 2005).”
Advances in Transgenic Rice Biotechnology (2007, background): “Paine et al . (2005) found that maize PSY gene could enhance the carotenoid content up to 37 μ g/g in ‘golden rice-2’ while testing the PSY gene from different organisms.”
Synthesis of carotenoids and regulation of the carotenoid biosynthesis pathway in response to high light stress in the unicellular microalga Chlamydomonas reinhardtii (2012, background): “However, in many cases, unexpected collateral effects, low functionality or silencing of the exogenous genes has reduced the productivity or viability of the new transgenic strains (Ye et al., 2000; Fraser et al., 2002; Paine et al., 2005; Diretto et al., 2007).”
Vitamin synthesis in plants: tocopherols and carotenoids. (2006, methodology): “A second generation of Golden Rice has been produced using the maize PSY, which in conjunction with a larger population of transgenics enabled the elevation of carotenoids by up to 23-fold (87).”
Modern Biotechnology as an Integral Supplement to Conventional Plant Breeding: The Prospects and Challenges (2006, methodology): “Paine et al. (2005) developed Golden Rice 2 by incorporating a phytoene synthase gene (psy) from maize in combination with the Erwinia uredovora gene used to generate the original Golden Rice.”
Travel advice on the road to carotenoids in plants. (2010, background): “Later, the corn gene encoding PSY proved more effective than the corresponding daffodil gene, resulting in a 17-fold increase in -carotene in ‘Golden Rice 2’ [70].”
Biofortification of crops with seven mineral elements often lacking in human diets--iron, zinc, copper, calcium, magnesium, selenium and iodine. (2009, background): “These include golden rice (Al-Babili & Beyer, 2005; Paine et al., 2005) and maize (Aluru et al.”
Carotenoid metabolism in plants. (2015, neutral): “Constitutive PSY overexpression has enhanced total carotenoid contents and substantially increased synthesis of b-carotene in canola seeds, cassava roots, potato tubers, endosperms, and in seed derived callus and roots (Shewmaker et al., 1999; Ducreux et al., 2005; Paine et al., 2005; Maass et al., ”
Molecular genetic approaches to increasing mineral availability and vitamin content of cereals (2007, methodology): “, 2003), using the phosphomannose isomerase selection system instead of antibiotic resistance, and replacement of the daffodil phytoene synthase gene with a gene from maize (Paine et al., 2005) (see Al Babili and Beyer, 2005 for review).”