Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

By S. Leibundgut-Landmann, O. Gross, M. Robinson, F. Osorio, Emma C Slack, S. Tsoni, E. Schweighoffer, V. Tybulewicz, Gordon D. Brown, J. Ruland and 1 more. Nature Immunology, 2007

1,277 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/ad559f1a1411d0f13a6bddcde333f28179aeb0e8

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In Epidemiology

1. Shizuo Akira
2. R. Medzhitov
3. Teresa Zelante
4. Paolo Puccetti
5. A. De Luca
6. F. Sallusto
7. Rafi Ahmed
8. L. Romani

In Immunology

1. D. Cua
2. Rafi Ahmed
3. Shizuo Akira
4. Bali Pulendran
5. R. Medzhitov
6. V. Kuchroo
7. Dan R. Littman
8. G. Barton

Citations in the corpus

• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “, 2000), and the fungal species (LeibundGut-Landmann et al., 2007), suggests that Th17 responses are triggered by specific pathogens and are required for their clearance.”
• Protein-glycan interactions in the control of innate and adaptive immune responses (2008, background): “For this signaling, the adaptor CARD9, which forms complexes with signaling molecules Bcl-10 and MALT1, is required, thus defining a pathway by which a CLR, independently of TLRs, regulates innate gene expressio”
• TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology (2007, background): “What are the sources of TGF-β in vivo that probably regulate the generation and function of T H -17 cells? In vitro , Foxp3 + T reg cells are sufficient sources of TGF-β for the polarization of T H -17 cell”
• Plasticity of CD4+ T cell lineage differentiation. (2009, background): “Fungal infections have been linked to IL-17 responses (LeibundGut-Landmann et al., 2007).”
• Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “In particular, the C-type lectin dectin-1 has emerged as an important participant in fungal recognition by DCs and in the induction of protective T helper type 1 (T H 1) and T H 17 immune response”
• Signalling through C-type lectin receptors: shaping immune responses (2009, background): “The collaboration between these pathways with unidentified pathways might explain the data showing that different dectin 1 ligands such as curdlan, fungi and zymosan induce distinct immune responses, including the development of T H 1, T H 17 and regulatory T cells 4, 65, 67 .”
• IL-17 and Th17 Cells. (2009, methodology): “Indeed, zymosan and curdlan, which are dectin agonists, induce secretion of IL-23 and have been used as adjuvants to skew the T cell response toward Th17 (32, 106).”