Plasticity of CD4+ T cell lineage differentiation.

By Liang Zhou, M. Chong, Dan R. Littman. Immunity, 2009

1,624 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2f5604fb5476c8c0392f524ffcbde2836fc17b4c

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In Immunology

1. I. Castro
2. T. Malek
3. Brigitta Stockinger
4. M. Veldhoen
5. Caroline L. Sokol
6. Di Yu
7. J. Allen
8. Rick M. Maizels

Citations in the corpus

• Diversity and dialogue in immunity to helminths (2011, background): “Fate competition can also operate when cells that are considered to be 'committed' to a particular T H cell subset are, in fact, relatively plastic and able to switch phenotype under the influence of a differing cytokine milie”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “Second, Foxp3+ CD25 Treg cells have more plasticity than Foxp3+ CD25+ to dedifferentiate into Th17 effector cells (Komatsu et al., 2009; Zhou et al., 2009).”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “Although the preferential expression of these chemokine receptors is apparent in vitro, there is some overlapping expression in vivo, which is not surprising given the relative plasticity between the various CD4+ T cell subsets (178).”
• Impact of genetic polymorphisms on human immune cell gene expression (2018, neutral): “Naïve CD4 + T cells when activated in vivo following pathogen exposure, differentiate into several lineage-specific memory subsets such as T H 1, T H 1/17, T H 17, T H 2, and T FH subsets (Zhou et al., 2009), which have distinct gene expression programs and functional roles in host defense (Fig.”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, neutral): “STAT5 binds to the promoter of the FoxP3 gene and it can promote Treg differentiation by regulating FoxP3 expression [40].”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, neutral): “This flexibility is called plasticity [102].”