Signalling through C-type lectin receptors: shaping immune responses

By Teunis B. Geijtenbeek, Sonja I Gringhuis. Nature reviews. Immunology, 2009

1,395 citations recorded by the source corpus.

C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates. Some CLRs can induce signalling pathways that directly activate nuclear factor-κB, whereas other CLRs affect signalling by Toll-like receptors. Dissecting these signalling pathways and their effects on host immune cells is essential to understand the molecular mechanisms involved in the induction of adaptive immune responses. In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2c1b5fbcffdd3116d625af3381bc0b81783761df

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Citations in the corpus

Antigen-presenting cell function in the tolerogenic liver environment (2010, background): “These molecules facilitate interactions with T cells, but also shape T cell immune function”
Immunological mechanisms of vaccination (2011, background): “In addition to TLRs, other types of PRRs, including the C-type lectin-like receptor”
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “Dendritic cells (DCs) induce the differentiation of helper T cells via the release of IL-1&beta”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “These include the mannose receptor, DC-SIGN, Dectin-1, and Mincle, although their cognate PAMPs have not yet been identified (Geijtenbeek and Gringhuis, 2009; Marakalala et al., 2010).”
Damage-Associated Molecular Patterns in Inflammatory Diseases (2018, background): “spleen tyrosine kinase (SYK) and RAF1 pathways (28).”
Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway (2011, background): “DC-SIGN recognizes high-mannose glycans from a variety of pathogens, and acts as a pattern recognition receptor bridging innate and adaptive immunit”
The SYK tyrosine kinase: a crucial player in diverse biological functions (2010, background): “The functional role of SYK in signalling by C-type lectins is discussed below; other aspects of these receptors can be found in excellent recent review”
Inflammation and its role in age-related macular degeneration (2016, background): “CLRs can be divided into two types of cell-associated and one type of soluble receptors [39].”
Coronavirus infections and immune responses (2020, background): “The second type is to activate the receptor by activating HAM‐like motifs in the intracellular tail of the receptor, such as Dectin‐1 (CLEC7A) and DNGR‐1 (CLEC9A).(28,29) Both mechanisms”
Pattern recognition receptors and inflammation. (2010, background): “The functions of CLRs are described in detail elsewhere (Geijtenbeek and Gringhuis, 2009), and here we give just a few examples of CLR-mediated microbial recognition.”