Alarmins: chemotactic activators of immune responses.

By J. Oppenheim, De Yang. Current Opinion in Immunology, 2005

816 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/ad048fdb559c6dc8268ef78c35d1ffd36390bd2f

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In Emergency Medical Services

In Immunology

In Microbiology

Citations in the corpus

Biochemical and functional characterization of three activated macrophage populations (2006, background): “M respond to a variety of stimuli, including microbial ligands for TLRs [3], endogenous “danger” signals [4], and cytokines.”
Acute Chorioamnionitis and Funisitis: Definition, Pathologic Features, and Clinical Significance (2015, background): “conditions or cell death can induce intraamniotic inflammation (“sterile inflammation”).(308-319) The diagnosis of this condition is one of exclusion and requires examination of the amniotic fluid with both cultivation and molecular microbiologic techniques.”
DAMPs, PAMPs and alarmins: all we need to know about danger (2007, background): “Other molecules may be added to the list, including cathelicidins, defensins and eosinophil-derived neurotoxin (EDN) [51], galectins [52], thymosins [53], nucleolin [54], and annexins [55; and 56, this issue]; more will emerge with time.”
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006, background): “In mammals, these peptides often have rather weak antimicrobial activity under physiological conditions, and their ability to modulate the immune response through a variety of mechanisms may be more importan”
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea (2007, background): “This function has led to use of the term 'alarmins”
HMGB1: Endogenous Danger Signaling (2008, background): “While the term PAMP is restricted to patterns located on pathogens, these endogenous analogues are termed alarmins (12).”
Liver inflammation and fibrosis. (2017, background): “Immune cells are activated by endogenous danger signals known as alarmins (18) or damage-associated molecular patterns (DAMPs), which are released by dead or damaged cells (19, 20).”
Apoptosis: controlled demolition at the cellular level (2008, background): “Necrotic cells almost invariably trigger inflammation by neutrophils, macrophages and other cells of the innate immune system, and recent evidence suggests that this is caused by the release of molecules (collectively called danger-associated molecular patterns (DAMPs) or alarmins) that stimulate on”
Disease-associated functions of IL-33: the new kid in the IL-1 family (2010, background): “Endogenous danger signals released in response to tissue injury and necrosis are referred to as 'alarmins', with PAMPs and alarmins collectively forming a family of damage-associated molecular pattern”
Macrophage activation by endogenous danger signals (2008, background): “A convenient and instructive term, ‘alarmins’, has been assigned to some of these endogenous stress signals [50].”