Macrophage activation by endogenous danger signals

By X. Zhang, DM Mosser. Journal of Pathology, 2008

610 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ddf8c4a4d264738175a223f4d8c340dffa9c2e0f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Edwards
2. D. Mosser
3. A. Manfredi
4. A. Mantovani
5. TA Wynn
6. Xia Zhang
7. Carol A. Colton
8. P. Murray

In Molecular Biology

1. D. Sohn
2. Jong Seong Roh
3. A. Manfredi

Citations in the corpus

• Role of Human Macrophage Polarization in Inflammation during Infectious Diseases (2018, background): “Against danger signals, the innate immune system initiates a protective inflammatory response through different phases, from destroying pathogens and removing cellular debris to repairing tissues and maintaining homeostasis [6].”
• Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing (2017, background): “Pro-inflammatory mediators interferon-γ (IFN-γ) and tumour necrosis factor (TNF), and damage associated pattern molecules (DAMPs) activate cells to produce ‘classically activated’ M1 macrophages (Figure 1) [11].”
• Macrophages and Tissue Injury: Agents of Defense or Destruction? (2011, background): “Macrophages are essential cellular effectors of the innate immune response, ridding the body of worn-out cells and debris—as well as viruses, bacteria, apoptotic cells, and some tumor cells—and mounting an inflammatory response following injury or infection (2).”
• Exploring the full spectrum of macrophage activation (2008, background): “In many cases the debris from necrosis is loaded with endogenous danger signals, such as heat-shock proteins, nuclear proteins (including HMGB1; high-mobility group box 1 protein), histones, DNA and other nucleotides, and components of the extracellular matrix that are cleaved by cellular protease”
• The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, background): “Nucleic acids, various proteins, metabolic intermediates and active, inflammatory cytokines are well accepted danger signals released by primary necrotic cells”
• Damage-Associated Molecular Patterns in Inflammatory Diseases (2018, background): “These DAMPs are recognized by macrophages, and inflammatory responses are triggered by different pathways, including TLRs and inflammasomes (10,11).”