Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

By Robert E. W. Hancock, H. Sahl. Nature Biotechnology, 2006

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Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “Besides having a direct antimicrobial activity, several AMPs display ability to modulate the innate immune responses of the host and thereby indirectly promote pathogen clearance (Hancock and Sahl, 2006; Yeung et al., 2011).”
Multifunctional Coatings to Simultaneously Promote Osseointegration and Prevent Infection of Orthopaedic Implants (2016, neutral): “AMPs are typically short, amphiphilic, cationic peptides that can interfere with microbial membranes and, upon entry into the cell cytoplasm, intracellular targets [133,134].”
Acinetobacter baumannii (2012, neutral): “The best studied cathelicidin is human LL-37; the only human cathelicidin, it exhibits both anti-tumor and anti-HIV activity.(71) The Tammar Wallaby cathelicidin WAM1 has been shown to be effective against Acinetobacter, and is 3–80 times more potent than LL-37 against a host of bacterial pathogens.”
Insights into Cronobacter sakazakii Biofilm Formation and Control Strategies in the Food Industry (2020, background): “These natural proteins can be found extensively in a diverse group of organisms including animals, plants, insects, and bacteria [107].”
Multifunctional cationic host defence peptides and their clinical applications (2011, methodology): “Nevertheless, clinical efficacy has been observed [34], e.”