Biochemical and functional characterization of three activated macrophage populations

By J. Edwards, Xia Zhang, Kenneth A. Frauwirth, D. Mosser. Journal of Leukocyte Biology, 2006

905 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7c5732da5984eeee57e481e8499eec081562e1c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Carol A. Colton
2. P. Murray
3. Xia Zhang
4. R. Gonçalves
5. David M. Mosser
6. J. Edwards
7. J. Gensel
8. Bei Zhang

In Molecular Biology

1. P. Murray
2. Carol A. Colton

Citations in the corpus

• IL-10: The Master Regulator of Immunity to Infection (2008, background): “Macrophages are potent antimicrobial effector cells that can participate in both proinflammatory (classical) and fibrotic (alternatively activated) responses (51).”
• Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, neutral): “This class is termed ‘M2b’ or Type II [21,50].”
• Macrophage activation and its role in repair and pathology after spinal cord injury. (2015, background): “M2b macrophage activation, therefore, is essential in the middle to later proliferative phase to trigger tissue remodeling (Edwards et al., 2006; Mosser and Edwards, 2008; Lech and Anders, 2013).”
• Macrophage Polarization. (2017, background): “IL-10 is often tied to M2 macrophages because it is produced in many settings from different immune cell types and because it is an essential and irreplaceable anti-inflammatory factor.”
• Macrophage activation and polarization: nomenclature and experimental guidelines (2014, neutral): “…has led to interpretive problems because Arg1 is also induced in M1 spectrum macrophages, expressed in some resident macrophage populations, and highly induced in mycobacteria-infected macrophages, further emphasizing the need for criteria encompassing multiple markers (El Kasmi et al., 2008).”
• Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “The term was originally derived from the association of this macrophage state with the TH2 adaptive immune responses and, hence, the term M2 has also been used to describe alternatively activated macrophages (Edwards et al. 2006; Mantovani et al. 2002; Mills et al. 2000; Mosser 2003).”
• Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “These macrophages do not act as antigen presenting cells, produce very small amounts of pro-inflammatory cytokines, and are inefficient at producing radicals [42].”
• Exploring the full spectrum of macrophage activation (2008, background): “This classification persists despite a growing body of evidence indicating that the M2 designation encompasses cells with dramatic differences in their biochemistry and physiolog”
• The M1 and M2 paradigm of macrophage activation: time for reassessment (2014, neutral): “This is another combined state, similar to the M1 combination of IFN-g + LPS, in which ligation of FcgRs on LPS-activated macrophages turns off IL-12 and induces IL-10 secretion in addition to upregulating antigen presentation and, importantly, promoting Th2 responses [46,47].”
• The Isolation and Characterization of Murine Macrophages (2008, methodology): “The use of macrophage-specific surface markers combined with flow cytometry represents the preferred technique to identify macrophages in tissue and to characterize their activation state (Cohn, 1978; Edwards et al., 2006; Gordon, 2007).”