Disease-associated functions of IL-33: the new kid in the IL-1 family

By F. Liew, N. Pitman, I. McInnes. Nature reviews. Immunology, 2010

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Pathophysiology of Cisplatin-Induced Acute Kidney Injury (2014, background): “IL-33 is also a chemoattractant for CD4+ T cells via its receptor, ST2R [87].”
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. (2014, background): “…signaling pathways in target cells expressing the ST2/IL-1RAcP receptor complex [3,4,6], including group 2 innate lymphoid cells (ILC2s, natural helper cells, nuocytes, innate helper 2 cells), mast cells and their progenitors, basophils, eosinophils, Th2 cells, NKT and NK cells [3,5,6].”
IL-33 is a crucial amplifier of innate rather than acquired immunity (2010, background): “As a Th2-inducing cytokine, IL-33 is considered to be involved in the development of allergic diseases such as atopic asthma (2, 3).”
THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE (2013, positive): “IL-33 is a driver of type 2 inflammatory conditions such as asthma, fibrosis, and response to parasites (Liew et al., 2010; McHedlidze et al., 2013; Sica et al., 2013).”