DAMPs, PAMPs and alarmins: all we need to know about danger

By M. Bianchi. Journal of Leukocyte Biology, 2007

2,915 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/325b2906f42dbb956001b60ecd98bd4685364934

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Kevin J. Tracey
2. H. Kono
3. K. Rock
4. J. Girard
5. C. Cayrol
6. U. Andersson
7. C. Rosales
8. A. Manfredi

In Molecular Biology

1. E. Latz
2. H. Kono
3. K. Rock
4. Kevin J. Tracey
5. J. Girard
6. C. Cayrol
7. C. Rosales
8. A. Manfredi

In Nutrition and Dietetics

1. C. Rosales
2. J. Girard
3. Kevin J. Tracey
4. H. Kono
5. K. Rock
6. A. Manfredi
7. C. Cayrol
8. Paul Martin

Citations in the corpus

• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “As the name suggests, alarmins serve as a siren to awaken the immune system, initiating and perpetuating a sterile inflammatory response in the CNS (FIGURE 3) (33).”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Yet, the immune system is capable of recognizing altered-self molecules in damaged cells through endogenously derived danger signals or alarmins (Bianchi, 2007; Garg et al., 2014).”
• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “The innate immune system is activated by a limited number of receptors that can recognize pathogen-associated or damage-associated molecular patterns [159,160].”
• The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’? (2008, background): “Based on these observations, we speculate that, similarly to HMGB1, IL-33 may function as an ‘alarmin’ belonging to the larger family of damageassociated molecular pattern (DAMP) molecules [23].”
• Macrophage activation by endogenous danger signals (2008, background): “Thus, alarmins and other endogenous danger molecules have been proposed to constitute a family of so-called ‘damageassociated molecular patterns’ (DAMPs) [51].”
• Wound repair at a glance (2009, background): “The same cells leak endogenous molecules, including damage-associated molecular pattern molecules (DAMPs), which might act as activation cues and/or chemotactic factors for other cells in the area (Bianchi, 2007).”
• Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release (2012, background): “High-mobility group box 1 (HMGB1) is a nuclear protein that signals tissue damage when released into the extracellular medium, and thus works as a damage-associated molecular pattern (DAMP; Bianchi, 2007).”
• Disease-associated functions of IL-33: the new kid in the IL-1 family (2010, background): “Endogenous danger signals released in response to tissue injury and necrosis are referred to as 'alarmins', with PAMPs and alarmins collectively forming a family of damage-associated molecular pattern”
• The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 (2009, background): “IL-33 may therefore represents a novel member of the damage-associated molecular pattern family, which regroups both endogenous (ie, alarmins) and exogenous (ie, pathogen-associated molecular patterns) danger signals (30).”