A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

By Joshua J. Forman, Aster Legesse-Miller, Hilary A. Coller. Proceedings of the National Academy of Sciences of the United States of America, 2008

632 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac684c19a95918b9fd3c20f9d6da27f59df2a13e

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Citations in the corpus

Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “Dicer is also regulated by its product let-7, which targets Dicer mRNA, creating a feedback loo”
Non‐coding RNAs: regulators of disease (2010, background): “Canonical and non-canonical targets are depicted for let-7a:HMGA2 [235] and let-7b:Dicer [87], respectively”
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, neutral): “Nevertheless, the use of artificial constructs demonstrated the absence of any mechanistic constraints that would prevent the targeting of other mRNA regions by miRNAs: let-7 target sites embedded in the coding sequence (CDS) were shown to be functional.(127) Analogously, the introduction of miRNA t”
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “…cleavage of mRNAs with near perfect complementary miRNA target sites in an RNA interference (RNAi)-like manner (Hutvagner and Zamore, 2002; Yekta et al, 2004), and certain miRNAs may function by targeting sites in the 50 UTR and ORF of mRNAs (Forman et al, 2008; Orom et al, 2008; Tay et al, 2008).”
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs (2013, background): “To determine whether H19 affects the expression of endogenous let-7 targets, pH19 was transfected into HEK293 cells and the levels of expression of two known let-7 targets Dicer (Forman et al., 2008; Tokumaru et al., 2008) and Hmga2 (Lee and Dutta, 2007) were analyzed.”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “The binding of miRNAs to 5 UTR and coding regions have silencing effects on gene expression (43, 44) while miRNA interaction with promoter”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, background): “The number of clusters annotated as derived from the 50UTR, CDS or 30UTR of target transcripts is shown (green bars).”
Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “RNAi-related small RNAs have emerged early during evolution , and have subsequently been adapted as guide RNAs in a wide range of genome and gene regulatory pathways (for review, see Zamore and Haley 2005; Ghildiyal and Zamore 2009).”
Biogenesis of small RNAs in animals (2009, background): “Levels of Drosha and Dicer are controlled by single-negative feedback to maintain the homeostasis of miRNA productio”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “A similar search for conserved motifs in coding regions in 17 vertebrate genomes identified several high-scoring, potential miRNA sites and led to the interesting finding that let-7 directly represses human Dicer mRNA through three sites in the OR”
Genetic variation in microRNA networks: the implications for cancer research (2010, neutral): “Let-7 directly targets DICER1 in its coding sequence, thus establishing a mechanism for a miRNA–DICER1 negative feedback loo”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “…regulated by its products; the identification of let-7 targeting sites within Dicer coding sequence suggests that let-7 miRNA directly targets Dicer, thus establishing a miRNA/Dicer autoregulatory negative feedback loop that might regulate the total rate of miRNA biogenesis (Forman et al., 2008).”